自制国产化支架-移植物腔内治疗腹主动脉瘤的实验研究

目的 探讨自制国产化支架、移植物在治疗犬腹主动脉瘤中的作用。方法 以国产镍钛合金丝纺织成网状管型支架，外套以国产真丝涤纶交织人造血管，装入导鞘制成支架-移植物系统；用胰蛋白酶灌注犬肾下腹主动脉段形成动脉瘤模型；用血管腔内技术将支架-移植物置入腹主动脉内，隔绝血流分别于第1周、1个月、3个月和6个月末观察通畅度及新生内膜生长。结果 20条模型犬接受手术，成功19条，支架置入后能充分展开并恢复形状，1个月末，支架内表面90%被新生内膜覆盖，3个月末几达100%，6个月末，79%的支架保持通畅，无移位、内漏等并发症。结论 自制国产化支架、移植物有良好的生物相容性和较高的通畅率，可用于腹主动脉瘤的治疗。

Experimental study of homemade domestic endovascular stent-graft treatment of abdominal aortic aneurysm

Objective To evaluate the effect of endovascular repair of abdominal aortic aneurysm (AAA) with homemade domestic stent graft. Methods Domestic Ni Ti alloy was knitted tubular mesh stents, wrapped with domestic silk dacron woven graft. The stent graft was inserted into introducer sheath. Perfusing the infrarenal abdominal aorta with trypsin developed canine AAA model. Stent graft was introduced with endovascular technique into the lumen of sac and anchored at the proximal and distal aorta of aneurysm. So the aneurysm was excluded from the blood circulation. The patency of stent graft and the growth of neointima were observed at intervals of 1 week, 1,3,6 months. Results Twenty canines received endovascular grafting. Nineteen cases were succeeded. After deployed stent unwrapped completely and restored the predermined shape. At 1st month the major part of the stent surface (90%) was covered patency was 79% and the sac was excluded completely. No migration and endoleak was seen. Conclusion Because of good compatibility and high patency, homemade domestic stent graft can be used in the treatment of AAA by endovascular technique.