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肿瘤体外药敏试验三磷酸腺苷生物发光法在肝癌化疗中的应用
引用本文:褚忠华,陈涛,区庆嘉,王捷,赵海燕,刘建平.肿瘤体外药敏试验三磷酸腺苷生物发光法在肝癌化疗中的应用[J].中华实验外科杂志,2002,19(3):235-236.
作者姓名:褚忠华  陈涛  区庆嘉  王捷  赵海燕  刘建平
作者单位:中山医科大学孙逸仙纪念医院普外科,广州,510120
基金项目:广东省社会重大科技基金资助项目(2KN0 4 50 8S)
摘    要:目的:探讨肿瘤体外药敏试验三磷酸腺苷生物发光法(ATP-TCA)在肝癌综合治疗中的应用。方法:取36例肝癌手术、活检和穿刺标本行ATP-TCA。结果:ATP-TCA的可评估率为94.44%;10种化疗药物的敏感率分别为:5-氟脲嘧啶(5-Fu)8.33%、诺消灵(MIT)8.33%、顺铂(CDDP)11.11%、草酸铂(OXA)13.89%、足叶已甙(VP-16)19.44%、丝裂霉素(MMC)25.00%、表阿霉素(EPI)27.78%、开普拓(CPT)44.44%、健择(GEM)47.22%、泰素(TAX)63.89%。结论:ATP-TCA法可用于肝癌化疗中化疗药物的筛选。

关 键 词:体外药敏试验  三磷酸腺苷  生物发光法  肝癌  化疗
修稿时间:2001年9月10日

The application of the ex vitro adenosine triphosphate tumor chemosensitivity assay in the chemotherapy of primary live cancer
CHU Zhonghua,CHEN Tao,OU Qingjia,et al..The application of the ex vitro adenosine triphosphate tumor chemosensitivity assay in the chemotherapy of primary live cancer[J].Chinese Journal of Experimental Surgery,2002,19(3):235-236.
Authors:CHU Zhonghua  CHEN Tao  OU Qingjia  
Institution:CHU Zhonghua,CHEN Tao,OU Qingjia,et al.Department of General Surgery,Memoral Hospital,Sun Yat sen University of Medical Sciences,Guangzhou 510120,China
Abstract:Objective To study the application of the ex vivo ATP tumor chemosensitivity assay (ATP TCA) in the chemotherapy of primary liver cancer.Methods The surgical and biopsied specimens of 36 patients were tested by the ATP TCA.Results Evaluable test results were achieved in 34 of 36 patients with the evaluability being 94.44%.The sensitive rate of 5 Fluoruracil (5 Fu),Mitoxantron (MIT),Cisplatin (CDDP),Oxaliplatin (OXA),Etoposid (VP 16),Mitomycin C (MMC),Epirubicin (EPI),Irinotecan (CPT),Gemcitabine (GEM),Paclitaxl (TAX) was 8.33%,8.33%,11.11%, 13.89%, 19.44%,25.00%,27.78%,44.44%,47.22%,and 63.89% respectively.Conclusion ATP TCA is a choice for the screening of chemotherapeutic drugs against primary liver cancer.
Keywords:Ex vivo chemosensitivity assay  Liver neoplasms  Chemotherapy  
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