高强度聚焦超声体外治疗人恶性实体肿瘤的病理学变化

目的 研究高强度聚焦超声（HIFU）体外治疗人恶性实体肿瘤的病理学变化。方法 HIFU治疗164例恶性实体肿瘤病人，其中30例治疗后常规外科手术，观察治疗区组织的病理学变化。结果 HIFU治疗区与非治疗区边界清楚，治疗区内组织出现凝固性坏死。组织学检查显示治疗区内全部肿瘤细胞出现不可逆性损伤征象，其边缘有新生肉芽组织形成和淋巴细胞浸润。结论 HIFU体外治疗恶性实体肿瘤是安全、有效和可行的，该技术将为临床无创性治疗肿瘤提供一种全新的治疗手段。

Pathological changes in human solid malignancies treated with ext racorporeal ablation of high-intensity focused ultrasound

Objective To study the pathological changes in human solid malignancies treated with extracorporeal ablation of high intensity focused ultrasound (HIFU). Methods HIFU treatment was performed on the 164 patients with malignant solid tumors. Among them, 30 patients routinely underwent surgical removal following HIFU treatment. The pathological changes in the treated tissues were observed. Results The treated tissues demonstrated homogenous coagulation necrosis and a clear boundary was shown between the treated and untreated area. Histological examination revealed an irreversible death of all tumor cells in the treated area, and the infiltration of lymphocytes as well as the formation of new granulation tissues in the border region between the treated and untreated area. Conclusion Extracorporeal treatment of human solid malignancies with HIFU was safe, effective and feasible. It could clinically provide a noninvasive therapy for human solid tumors.