检测胆囊结石胆汁中L型细菌的研究及其意义

目的 探讨L型细菌在胆囊结石、胆囊炎发病中的意义。方法 应用高渗培养技术对130例胆囊结石、胆囊炎及20例非胆道疾病的患者胆囊胆汁标本进行普通菌及L型菌联合培养。结果 L型菌总检出率胆囊疾病组为59.2%，对照组为5.0%；胆囊结石胆汁中，检出率最高为胆色素类结石（88.9%)，其次为混合性胆石（80.0%)、胆固醇结石（54.8%)和黑色结石（50.0%)；多发结石明显高于单个结石，随年龄增加，其感染检出率增高。结论 L型菌感染可能在胆囊结石、胆囊炎发生发展中有重要意义。临床上应重视其检测和治疗。

L-form bacteriologic assessment of bile from gallbladder in patients with gallstones and cholecystitis and implication

Objective To evaluate the role of L form bacteria in the development of gallstone and cholecystitis. Methods A L form bacteriological study was made on 130 patients undergoing elective surgery for gallbladder diseases and 20 subjects with a normal biliary tract as a control group. Results The positive rate of bacterial L form was 59.2 % in benign gallbladder diseases and 5.0 % in the control group. In the bile from gallbladder, the detectable rate for pigment stones was the highest (88.9 %), followed by mixed, cholesterol and black stones (80.0 %, 54.8 % and 50.0 % respectively). There was relationship between the number of gallstone and the L form bacterial positive rate, as well as the age of the patients. Conclusion L form bacterial infection might play a certain role in stone formation in gallbladder and the therapy for L form bacterial infection in the patients with gallstones and chronic cholecystitis should be performed clinically.