“骨水泥反应综合征”发生机制的实验研究

目的通过动物实验探讨股骨髓腔填塞骨水泥引发“骨水泥反应综合征”的发生机制。方法14只实验兔开放一侧股骨髓腔，制备髋关节置换模型，根据填塞材料不同随机分为两组。A组：面团期骨水泥组；B组：普通面粉团组。填塞后持续动态观察实验动物的血压变化；血气分析检测血氧分压的变化；切片观察实验动物肺和心脏的病理改变；检测血清β血栓球蛋白（β-TG）和转化生长因子（TGF-β1）等血小板活化指标。结果A组7例有6例出现明显的血压下降、心律异常和氧分压下降，其中2例死亡。病理检查显示肺内脂肪栓塞和骨组织栓塞表现。B组7例均有类似血压下降以及肺部栓塞表现。两组均未见血小板活化指标的改变。结论“骨水泥反应综合征”与骨水泥的理化性质或单体毒性可能没有直接关系，其发生与髓腔压力增高导致的肺部栓塞密切相关。

Experimental study on the mechanism of "bone cement response syndrome"

Objective To investigate the mechanism of bone cement response syndrome caused by filling the medullary cavity with the acrylic bone cement. Methods Fourteen rabbits were randomly divided into two groups according to different filling materials. Group A: bone cement group; Group B: flour group. The opened femur medullary cavities of rabbits were filled with the bone cement in dough stage or flour, simulating the insertion of the femoral stem in cemented hip arthroplasty. The fluctuations of blood pressure a...