臭氧联合玻璃酸钠治疗膝骨性关节炎的疗效观察

目的]观察医用臭氧(O3)联合玻璃酸钠(SH)治疗膝骨性关节炎的临床疗效。方法]选择120例膝骨性关节炎患者,随机分为A、B、C三组,每组40例。其中A组第1周关节腔内注射15ml(35ug/ml)的医用臭氧,第2周注射玻璃酸钠25mg,第3周注射15ml(35ug/ml)的医用臭氧;B组关节腔内注射15ml/周的医用臭氧,每周1次,连续3次为1疗程;C组关节腔内注射玻璃酸钠25mg/周,每周1次,连续5次为1疗程,比较三组病例治疗前及治疗后1、2、3个月VAS值和治疗效果。结果]三组患者治疗后VAS评分与治疗前相比均有降低(P0.01),在治疗后的第1、2、3个月同一时点,A组疼痛缓解最明显,VAS评分三组相比差异有统计学意义(P0.05,P0.01)。A组膝关节功能的优良率要高于对照组,差异有统计学意义(P0.05和P0.01)。全部患者未见明显的不良反应和副作用。结论]医用臭氧联合玻璃酸钠治疗膝骨性关节炎能有效解除关节疼痛,改善关节活动度,临床疗效优于臭氧、玻璃酸钠单独应用。是一种治疗膝骨性关节炎的优势方法。

Clinical results of medical ozone combined with sodium hyaluronate for knee osteoarthritis

Objective] To observe the clinical effects of medical ozone(O3)combined with sodium hyaluronate(SH)in treatment of knee osteoarthritis.Methods]One hundred and twenty patients with knee osteoarthritis were randomly divided into three groups:A,B and C(40 in each group).The patients in group A were treated with intra-articular injection of 15 ml(35 ug/ml)medical ozone in the first week,25 mg sodium hyaluronate in the second week and repeated 15 ml(35 ug/ml)medical ozone in the third week.The patients in grou...