综合骨库在现代矫形外科中的作用

目的]介绍并分享综合骨库建立20年来的成功经验;探讨骨库在现代矫形外科中的地位和作用.方法]提供并总结分析综合骨库自1988～2007年间有关同种异体骨,系列异种骨生产、使用的数据.结果]同种骨:得到死亡供体69具,存活供体88例;收获半关节540件,骨板237件,松质骨粒2 632份;以上同种骨共使用于1 390例病人;系列异种骨:重组合异种骨2 495份,抗感染重组合异种骨208份,注射型BMP 542份,系列异种骨共使用于2 771例病人;20年来,共培训骨库技术人员18名,培养博士48名,硕士36名.结论]临床植骨材料需求量大,在细胞型组织工程尚无满意的产品问世前,综合骨库所提供的异种骨和同种骨根据不同的植骨需要,取长补短,相互补充,使之成为最理想的选择.综合骨库这种集加工生产,科研开发及教学培训于一体的运行模式必将在中国的组织库事业中发挥愈加重要的作用.

Effect of multi-variety bone bank in contemporary orthopaedics

Objective] To discuss the effect and the role of the multi-variety bone bank in contemporary orthopaedics by introducing and sharing a 20 - year experience with the multi - variety bone bank. Methods] Data on a variety of bone grafts were provided by the multi - variety bone bank. Bone retrievals by the author' s teams from January 1998 to December 2007 were summarized and analyzed. Results] Allografts: a total of 540 hemi -joints, 237 cortical bone plates and 2632 packages of cancellous bone granules were obtained from 157 bone donors (88 living donors and 69 cadavers), and were applied to 1390 patients. Xenografts variety: 2495 packages of reconstituted bone xenografts and 208 packages of anti - infected reconstituted bone xenografts and injectable BMP xenografts were used on 2771 patients. Professional training: a total of 18 technical staff members, 36 postgraduates for master' s degree and 48 for doctor' s degree were trained in the author' s multi -variety bone -bank. Conclusion] A large quantity of bone materials was required in the clinic and presently there is no tissue engineering products permitted for use by the State Food and Drug Administration of China (SFDA) . Thus, both the bone allografts and bone xenografts could be selected as substitutes for the diverse requirements of bone grafts. The pattern of integration with processing , preservation, research and development in this multi - variety bone bank inevitably playes an important role in the Chinese tissue banking enterprise.