鱼油治疗IgA肾病的Meta分析

目的 采用Meta分析的方法评价鱼油治疗IgA肾病的疗效，为临床实践提供理论依据。 方法 计算机检索Cochrane 图书馆、PubMed、EMBASE、中国知网等数据库。文献检索起止时间均从建库至2009年9月，收集鱼油治疗IgA肾病的随机对照试验（RCT），提取资料后使用Revman 软件5.0进行数据分析。 结果 共纳入6个研究，包括258例对象。Meta分析结果显示，与对照组比较，鱼油组蛋白尿水平下降，差异有统计学意义SMD=-0.27，95%CI（-0.52~-0.03），P=0.03]；鱼油组肾小球滤过率（GFR）下降，差异有统计学意义SMD=0.30，95%CI（0.05~0.55），P=0.02]。 结论 鱼油虽可以降低IgA肾病患者的蛋白尿，但并不能维持肾功能稳定。

Meta-analysis of fish oil in the treatment of IgA nephropathy

Objective To assess the efficacy of fish oil in the treatment of IgA nephropathy using the method of Meta-analysis. Methods Randomized controlled trials of fish oil in the treatment of IgA nephropathy were searched in the database of Cochrane library,PubMed, EMBASE and CNKI. Data extracted from the literatures were analyzed with Revman software (version 5.0). Results In comparison with the controlled group, proteinuria in the fish oil group was significantly decreased SMD=-0.27, 95%CI (-0.52 to -0.03), P=0.03], while the renal function deteriorated SMD=0.30,95%CI(0.05 to 0.55), P=0.02]. Conclusion Fish oil can decrease the proteinuria of IgA nephropathy, but can not prevent renal function from deterioration.