| 乙型肝炎病毒相关性肾炎的相关因素分析 |
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| 引用本文： | 蔡建芳,窦晓丽,文煜冰,叶葳,刘炳岩,叶文玲,徐红,陶建瓴,范洪伟,刘晓清,李航,李雪梅.乙型肝炎病毒相关性肾炎的相关因素分析[J].中华肾脏病杂志,2011,27(2):96-99. |
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| 作者姓名： | 蔡建芳 窦晓丽 文煜冰 叶葳 刘炳岩 叶文玲 徐红 陶建瓴 范洪伟 刘晓清 李航 李雪梅 |
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| 作者单位： | DOI：10.3760/cma.j.issn.1001-7097.2011.02.007 基金项目：北京协和医院青年科研基金 作者单位：100730北京，中国医学科学院北京协和医院肾内科（蔡建芳、文煜冰、叶葳、刘炳岩、叶文玲、徐红、陶建瓴、李航、李雪梅），临床流行病学中心（刘晓清），感染科（范洪伟）；河北省廊坊市人民医院肾内科（窦晓丽） 通信作者：李雪梅，Email: 0605.mei@gmail.com |
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| 基金项目： | 北京协和医院青年科研基金 |
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| 摘 要： | 目的 研究乙型肝炎病毒相关性肾炎（HBV-GN）的相关因素。 方法 采用回顾性病例对照研究。用Logistic回归对86例HBV-GN患者及135例非HBV-GN慢性HBV感染者进行比较。 结果 单因素分析结果显示，HBV-GN与男性（OR 2.79，95％CI 1.48～5.25，P = 0.001）、HBeAg阳性（OR 2.60，95％CI 1.49～4.53，P = 0.001）、HBV复制（OR 3.63，95％CI 1.80～7.33，P < 0.01）、肝硬化（OR 4.58，95％CI 1.41～14.91，P = 0.011)及谷丙转氨酶（ALT）升高（OR 2.53，95％CI 1.42～4.51，P = 0.002)相关。多因素分析结果显示，HBV-GN与男性（OR 2.21，95%CI 1.12～4.33，P = 0.022）、HBV复制（OR 2.77，95%CI 1.28～5.97，P = 0.01）、肝硬化（OR 4.55，95%CI 1.29～16.10，P = 0.019）及ALT升高（OR 1.96，95%CI 1.04～3.69，P = 0.037）相关。HBV-GN中，与IgA肾病型（HBV-IgAN）比较，单因素分析结果显示，经典型HBV-GN（膜性肾病或膜增生性肾炎型）与男性（OR 5.24，95％CI 1.64～16.81，P = 0.005）、HBV复制（OR 8.02，95％CI 2.15～29.84，P = 0.002）及ALT升高（OR 3.10，95％CI 1.00～9.67，P = 0.051）相关；多因素分析结果显示，仅与男性（OR 6.51，95%CI 1.76～24.11，P = 0.005）及HBV复制（OR 7.22，95%CI 1.68～30.97，P = 0.008）相关。结论 男性、HBV复制、肝硬化及ALT升高都可能是HBV-GN的易患因素。与HBV-IgAN比较，经典型HBV-GN与病毒复制及男性更相关，两者可能有不同的病理机制。
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| 关 键 词： | 乙型肝炎病毒 因素分析统计学 乙型肝炎病毒相关性肾炎 |
Analysis on relevant factors for hepatitis B virus-associated glomerulonephritis |
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| CAI Jian-fang,DOU Xiao-li,WEN Yu-bing,YE Wei,LIU Bing-yan,YE Wen-ling,XU Hong,TAO Jian-ling,FAN Hong-wei,LIU Xiao-qing,LI Hang,LI Xue-mei.Analysis on relevant factors for hepatitis B virus-associated glomerulonephritis[J].Chinese Journal of Nephrology,2011,27(2):96-99. |
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| Authors: | CAI Jian-fang DOU Xiao-li WEN Yu-bing YE Wei LIU Bing-yan YE Wen-ling XU Hong TAO Jian-ling FAN Hong-wei LIU Xiao-qing LI Hang LI Xue-mei |
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| Institution: | Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China Corresponding author: LI Xue-mei, Email: 0605.mei@gmail.com |
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| Abstract: | Objective To retrospectively evaluate the relevant factors for hepatitis B virus-associated glomerulonephritis (HBV-GN).Methods A total of 86 patients with pathologyproven HBV-GN and 135 HBV carriers with non-HBV-GN were included in this retrospective casecontrol study.Logistic regression analysis was used to detect the relevant factors for HBV-GN.Results On univariate analysis,the factors associated with HBV-GN were as follows: male (OR 2.79,95%CI 1.48-5.25,P=0.001),HBeAg positivity (OR 2.60,95%CI 1.49-4.53,P=0.001),HBV replication (OR 3.63,95%CI 1.80-7.33,P＜0.01),liver cirrhosis (OR 4.58,95%CI 1.41-14.91,P=0.011),and elevated alanine aminotransferase (ALT) (OR 2.53,95%CI 1.42-4.51,P=0.002).On multivariate analysis,the associations remained significant for male (OR 2.21,95%CI 1.12-4.33,P=0.022),HBV replication (OR 2.77,95%CI 1.28-5.97,P=0.01),liver cirrhosis (0R 4.55,95%CI 1.29-16.10,P=0.019) and elevated ALT (OR 1.96,95%CI 1.04-3.69,P=0.037).Compared with HBV-associated IgA nephritis (HBV-IgAN) in multivariate model,HBV-associated membranous nephropathy (HBV-MN) or membranoproliferative glomerulonephritis (HBV-MPGN) was significantly associated with male (OR 6.51,95%CI 1.76-24.11,P=0.005) and HBV replication (OR 7.22,95%CI 1.68-30.97,P=0.008).Conclusions Male,HBV replication,liver cirrhosis and elevated ALT may be predictive factors for HBV-GN.Compared with HBV-IgAN,HBV-MN or HBV-MPGN is significantly associated with male and HBV replication. |
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| Keywords: | Hepatitis B Virus Factors analysis statistical Hepatitis B virus associated glomerulonephritis |
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