| 老年髋部骨折局部胰岛素样生长因子及其结合蛋白表达的研究 |
| |
| 引用本文： | 梁朝革,唐献忠,徐志英,陈豪杰,岳雄,王嘉,徐刚,张鹏.老年髋部骨折局部胰岛素样生长因子及其结合蛋白表达的研究[J].中国骨与关节损伤杂志,2011,26(8):692-693. |
| |
| 作者姓名： | 梁朝革 唐献忠 徐志英 陈豪杰 岳雄 王嘉 徐刚 张鹏 |
| |
| 作者单位： | 上海市长宁区中心医院骨科 200336 |
| |
| 摘 要： | 目的 研究不同类型老年女性髋部骨折中局部胰岛素样生长因子1 (IGF-1)及血清胰岛素样生长因子结合蛋白3、4、5(IGF-BP-3、4、5)表达差异.方法 选取年龄大于65岁老年女性髋部骨折46例,比较局部IGF-1及IGFBP-3、4、5蛋白表达差异.结果 股骨粗隆间骨折组粗隆区BMD较股骨颈骨折组低(P ＜0.001),局部蛋白表达只有IGFBP-4存在差异(P=0.004).结论 局部IGF-BP-4表达的差异可能是导致不同类型老年髋部骨折的病理机制之一,但由于IGF-1及其结合蛋白调节机制相当复杂,对于IGF-1及IGFBPs表达机制同骨折类型的关系尚需大量的实验研究进一步证实.
|
| 关 键 词： | 股骨颈骨折 股骨粗隆间骨折 血清胰岛素样生长因子1 血清胰岛素样生长因子结合蛋白3、4、5 |
Local Expressions of Insulin-like Growth Factor(IGF) System in Senile Female Patients with Femoral Neck Versus Intertrochanteric Fracture |
| |
| Liang Chaoge
,
Tang Xianzhong
,
Xu Zhiying
,
Chen Hao-jie
,
Yue Xiong
,
Wang Jia
,
Xu Gang
,
Zhang Peng.Local Expressions of Insulin-like Growth Factor(IGF) System in Senile Female Patients with Femoral Neck Versus Intertrochanteric Fracture[J].Chinese Journal of Bone and Joint Injury,2011,26(8):692-693. |
| |
| Authors: | Liang Chaoge Tang Xianzhong Xu Zhiying Chen Hao-jie Yue Xiong Wang Jia Xu Gang Zhang Peng |
| |
| Institution: | Liang Chaoge,Tang Xianzhong,Xu Zhiying,et al.Department of Orthopaedics,the Central Hospital of Changning District,Shanghai,200336 |
| |
| Abstract: | Objective To investigate differences of local insulin-like growth factor-1(IGF-1) and IGF-binding protein-3,4,5(IGFBP-3,4,5)expressions,in female senile hip fracture of two types.Methods The differences of local IGF-1 and IGFBP-3,4,5 expressions in selected female sufferers of senile hip fracture aged over 65 were examined and compared.Results Among 46 cases,BMD,and local protein expression of IGFBP-4 in the intertrochanteric fracture group were higher than that of in the femoral neck fracture group(P <0.00... |
| |
| Keywords: | Femoral neck fracture Femoral intertrochanteric fracture IGF-1 IGFBP-3 4 5 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
