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糖尿病肾病患者血清vaspin与血清脂联素的相关性
引用本文:彭艳哲,邓开慧,达静静,皮明婧,冉燕,吴静,查艳.糖尿病肾病患者血清vaspin与血清脂联素的相关性[J].国际移植与血液净化杂志,2016(2):37-40.
作者姓名:彭艳哲  邓开慧  达静静  皮明婧  冉燕  吴静  查艳
作者单位:1. 贵州省人民医院肾内科, 贵阳,550002;2. 贵州医科大学附属第二医院
基金项目:国家自然科学基金(812005390),贵州省科技计划基金项目(黔科合LH字[2014]7002号),贵州省科技计划基金项目(黔科合LH字[2015]7154号),贵州省科技计划基金项目(黔科合LH字[2015]7155号),贵州省卫计委基金项目(gzwkj2014-1-046)
摘    要:目的 探讨血清vaspin、血清脂联素水平与糖尿病肾病的相关性.方法 选择120例2型糖尿病患者,据尿白蛋白排泄率分为正常蛋白尿组(尿白蛋白排泄率< 20μg/min)40例、微量蛋白尿组(尿白蛋白排泄率20~200 μg/min)45例、大量蛋白尿组(尿白蛋白排泄率>200μg/min)35例,另选健康体检者40名为对照组.分别采用酶联免疫吸附法测定空腹vaspin、脂联素水平,同时测定空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹胰岛素、尿素氮、血肌酐,测量体质指数、腰围、收缩压和舒张压,比较各组间差异.结果 3组患者较对照组血清vaspin、脂联素水平显著升高,差异有统计学意义(P<0.05).3组患者随着尿白蛋白排泄率升高,血清vaspin水平逐渐降低,差异无统计学意义(P>0.05);随着尿白蛋白排泄率升高,血清脂联素水平逐渐升高,差异有统计学意义(P<0.05).血清vaspin与体质指数、腰围、收缩压、空腹血糖、甘油三酯、空腹胰岛素呈正相关(P<0.05);血清脂联素与空腹血糖、高密度脂蛋白胆固醇、空腹胰岛素、血肌酐呈正相关.结论 脂联素和vaspin均与糖尿病肾病有一定相关性,血清脂联素水平随着糖尿病肾病进展不断升高,而vaspin则随糖尿病肾病的进展下降.

关 键 词:糖尿病肾病  vaspin  脂联素

Relationship between serum levels of adiponectin and vaspin and diabetic nephropathy
Abstract:Objective To explore the relationship between serum adiponectin and vaspin and diabetic nephropathy in type 2 diabetic patients with nephropathy.Methods A total of 120 patients with type 2 diabetes mellitus were divided into three groups according to the urinary albumin excretion rate (UAER):normal albuminuria group (UAER < 20 μg/min,n =40),micro-albuminuria group(UAER 20-200 μg/min,n =45) and macro-albuminuria group (UAER > 200 μg/min,n =35).Forty healthy subjects were included as the control group.Serum levels of adiponectin and vaspin were measured by enzyme linked immunosorbent assay (ELISA).Then,fasting plasma glucose (FPG),triglyceride (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),urea nitrogen (BUN),serum creatinine (Cr) and fasting insulin (Fins) levels together with UAER were determined.Results The serum levels of adiponectin and vaspin of the diabetic patients were significantly higher than those in the control group (P < 0.01).Three groups of the patients with increasing UAER,serum vaspin levels gradually decreased,there was no statistically significant difference (P > 0.05).With increasing UAER,serum adiponectin level increased (P < 0.01).Serum vaspin and body mass index (BMI),WC,systolic blood pressure (SBP),FPG,triglycide (TG),fasting insulin (Fins) positive correlation (P < 0.01).Serum adiponectin and FPG,Fins,HDL-C level,Cr was related.Conclusion Adiponectin and vaspin has certain correlation with diabetic ncphropathy,serum adiponectin level along with the progress of diabetic nephropathy rising,while vaspin drops as the progress of diabetic nephropathy.
Keywords:Diabetic nephropathy  Vaspin  Adiponectin
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