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NF-1在瘢痕疙瘩中表达的研究
引用本文:王惠东,郑江红,邓辰亮,宋楠,吴娟娟,张世新,丁志,茅广宇,葛岚,赵喜彬,杨松林. NF-1在瘢痕疙瘩中表达的研究[J]. 中国美容医学, 2009, 18(4): 497-499
作者姓名:王惠东  郑江红  邓辰亮  宋楠  吴娟娟  张世新  丁志  茅广宇  葛岚  赵喜彬  杨松林
作者单位:1. 上海交通大学附属第六人民医院整形科,上海,200233
2. 上海交通大学附属第九人民医院上海组织工程中心,上海,200011
摘    要:目的:通过比较人瘢痕疙瘩与正常皮肤组织中NF-1(nulear factor 1)在mRNA水平的表达量,来研究该基因在瘢痕疙瘩中发生的变化,并探讨其意义。方法:收集了3例正常皮肤标本和3例瘢痕疙瘩标本,用荧光定量PCR分别检测两种组织中NF-1在mRNA水平的表达量。结果:正常皮肤组和瘢痕疙瘩组中NF-1在mRNA水平的表达差异显著(P〈0.05),正常皮肤组中NF-1的表达量是瘢痕疙瘩组的35倍。结论:NF-1 mRNA的高表达可能与瘢痕疙瘩疙瘩的发生相关,具体机制尚需进一步研究。

关 键 词:瘢痕疙瘩  转录因子  NF-1

Study of NF-1 Expression in Keloid
WANG Hui-dong,ZHENG Jiang-hong,DENG Chen-liang,SONG Nan,WU Juan-juan,ZHANG Shi-xin,DING Zhi,MAO Guang-yu,GE Lan,ZHAO Xi-bin,YANG Song-lin. Study of NF-1 Expression in Keloid[J]. Chinese Journal of Aesthetic Medicine, 2009, 18(4): 497-499
Authors:WANG Hui-dong  ZHENG Jiang-hong  DENG Chen-liang  SONG Nan  WU Juan-juan  ZHANG Shi-xin  DING Zhi  MAO Guang-yu  GE Lan  ZHAO Xi-bin  YANG Song-lin
Affiliation:1.Department of Plastic Surgery;the 6th People's Hospital;Shanghai Jiaotong University;Shanghai 200233;China;2.The Tissue Engineering Center of Shanghai;the 9th People's Hospital;Shanghai 200011;China
Abstract:Objective To investigate the changes and significance of NF-1 expression based on the comparison of NF-1 mRNA expression between keloid and normal skin tissue.Methods Keloid and normal skin tissues were collected,then NF-1 mRNA expression in keloid and normal skin tissues were detected respectively with realtime qualitative PCR.Results The difference of NF-1 mRNA expression between keloid group and normal skin group is statistically significant(P<0.05),the NF-1 mRNA expression in keloid group is 35 times hi...
Keywords:NF-1
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