胃癌组织中CX3CR1的表达研究

目的 探讨CX3CR1在胃癌组织的表达及其意义.方法 收集30例胃癌患者手术切除的癌组织及对应癌旁组织,采用Western blot和免疫组织化学法对CX3CR1在蛋白质水平上进行检测.结果 Western blot和免疫组织化学法显示30例胃癌组织和对应癌旁组织中均存在CX3CR1蛋白的表达,CX3CR1蛋白在胃癌组织中的表达水平高于对应癌旁组织（P＜0.05）;免疫组织化学法显示胃癌组织中CX3CR1蛋白的表达主要位于癌细胞.结论 胃癌组织中CX3CR1的高表达可能与胃癌的发生发展密切相关.

Expression of CX3CR1 in human gastric cancer

Objective To cleteci the expression and significance of CX3CR1 in human gastric cancer. Methods The primary tumor tissues and matching adjacent non-cancerous tissues from 30 gastric cancer patients were collected. CX3CR1 protein levels were detected by Western blot and immunohisto- chemistry analysis. Results Western blot and immunohistochemistry analysis demonstrated that CX3CR1 protein was expressed in both 30 gastric cancer tissues and matching adjacent non-cancerous tissues. The mean expression level of CX3CR1 protein in the gastric cancer tissues was higher than that in the matching adjacent non-cancerous tissues（P 〈 0.05 ）. Immunohistochemistry analysis also demonstrated that the ex- pression of CX3CR1 protein in gastric cancer tissue mainly located in the cancer cells. Conclusion High CX3CR1 expression may play a critical role in the occurrence and development of gastric cancer.