Notch信号通路在骨重建过程中的双向调节作用

Notch信号通路对骨形成及骨吸收的刺激和抑制作用都被广泛报道,其在成骨细胞、骨细胞、破骨细胞、骨髓间充质干细胞等的生成或分化中的作用出现了"矛盾"的结果,表现为对于骨形成-骨吸收偶联关系的双向调节作用,可见,Notch信号通路对骨重建过程的影响并非单一的促进或抑制作用,本文就Notch信号通路对成骨细胞、破骨细胞、骨髓间充质干细胞生成、分化及功能的双向调节作用做一综述,以期为相关骨代谢疾病的研究思路提供参考。

Bidirectional regulation of Notch signaling pathway during bone remodeling

Notch signaling pathway has been widely reported for its stimulatory and inhibitory effects on bone formation and bone resorption. Its role in the formation or differentiation of osteoblasts, bone cells, osteoclasts, and bone marrow mesenchymal stem cells appears to be contradictory, and shows a kind of bidirectional regulation for the coupling of bone formation to bone resorption. The effect of Notch signaling pathway on bone remodeling process is not a single promotion or inhibition. This article reviews the role of Notch signaling pathway in the bidirectional regulation of osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells. We hope to provide reference for relevant research ideas of bone metabolism diseases related to the Notch signaling pathway.