强直性脊柱炎患者的骨密度变化

目的 评价强直性脊柱炎患者的骨密度变化，探讨其骨代谢改变的病因和发病机理。方法 采用前瞻性健康对照研究方法，对67例强直性脊柱炎患者以双能X线吸收法测定腰椎、股骨颈、股骨粗隆和Ward三角区骨密度，同时检测骨钙素、降钙素、血钙及炎症急时相反应指标，并与健康对照组进行比较。结果 强直性脊柱炎骨密度与对照组比较：股骨颈、股骨粗隆和Ward三角区骨密度显著降低，早期患者的腰椎骨密度显著降低；血清骨钙素水平较对照组显著降低；骨密度指标与炎症急时相反应指标呈负相关。结论 强直性脊柱炎患者的骨密度降低，其原因应是免疫炎症反应、运动受限等多种因素作用的结果。

Bone mineral density in patients with ankyosing spondylitis

Objective To evaluate bone mineral density (BMD) in patients with ankylosing spondylitis (AS), and explore the etiology and pathogenic mechanism of changes in bone metabolism.Methods In the prospective controlled study, BMD were determined by dual energy X-ray absorptiometry (DEXA) at hip and spine in 67 cases of AS. Meanwhile, bone glyprotein, human calcitonin, serum calcium and inflammatory indices of acute phase reactants in the patients with AS were examined, and compared with healthy controls. Results Patients with AS had significantly reduced BMD in femoral neck, Ward's triangle and frochanter. Compared with controls, patients with early AS had significant reduced BMD of the lumbar spines. The patients had significantly lower mean serum bone glaprotein than the controls. Conclusions BMD is reduced in patients with AS. The reason is multiple including immune inflammatory reaction and limitation of movement.