年龄和雌激素对绝经后妇女骨转换生化指标的影响

目的调查骨转换生化指标的差异,并评估激素和年龄相关因素与绝经前和绝经后妇女生化指标的关系。方法选取在2016年1月至2018年1月期间在我院就诊的女性患者作为研究对象。根据问卷调查,共选出496名健康女性,其中绝经前244例,绝经后女性252例。根据试剂制造商提供的指南评估不同的骨标志物,并且采用化学发光免疫测定法进行激素测定,特别是雌二醇水平评估。结果与绝经前妇女相比,绝经后妇女血清钙水平和雌二醇水平显著降低,而绝经后妇女血清磷和碱性磷酸酶(ALP)水平显著升高(P0.05)。年龄与绝经后骨标志物(ALP和钙)显著相关(P 0.05),而绝经前组无显著相关性。绝经后妇女钙与雌二醇之间呈显著正相关,而ALP与雌二醇之间呈显著负相关。此外,在体质指数和年龄校正偏相关分析中,绝经后妇女雌二醇和骨标志物之间没有显著相关性。结论绝经后女性雌激素水平和骨代谢异常对骨质疏松症的预测有积极的意义。

Effects of age and estrogen on bone turnover biochemical markers in postmenopausal women

Objective To investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors and biochemical markers between pre- and postmenopausal women. Methods The female patients who were present in our hospital during January 2016 to January 2018 were selected as the study subjects. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated base on the guideline provided by the reagent manufacturer. Hormonal assay, particularly estradiol level assessment, was measured with chemiluminescence immunoassay-based technique. Results A significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women. A significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal women (P<0.05). Age was significantly correlated with bone markers (ALP and calcium) in post-menopausal group (P<0.05), but it was not significantly correlated in premenopausal group. In addition, there was significant positive correlation between calcium and estradiol in postmenopausal women, while ALP was negatively correlated with estradiol in that group. Further, no significant correlation was demonstrated in body mass index and age-adjusted partial correlation analysis between estradiol and bone markers in postmenopausal women. Conclusion Concern about the postmenopausal women''s estrogen levels and abnormal bone metabolism has a positive significance for the prediction of osteoporosis.