血清胃饥饿素水平与绝经后骨质疏松症合并代谢综合征患者骨密度相关性研究

目的探索胃饥饿素与绝经后骨质疏松症合并代谢综合征患者骨密度相关性。方法本研究纳入我院初诊未经治疗的绝经后骨质疏松症患者(T评分<-2.5)参加了研究,共纳入320位绝经后骨质疏松症女性受试者,其中绝经后骨质疏松症合并代谢综合征78位,绝经后骨质疏松症女性不合并代谢综合征242位。采用酶联免疫吸附法测定血清胃饥饿素和骨代谢指标水平。采用双能X线骨密度仪测量各研究对象腰椎(L1-L4)和股骨颈的骨密度。变量间的相关分析采用Pearson相关分析。结果绝经后骨质疏松症组(OP)和绝经后骨质疏松症合并代谢综合征组(OPMS)的身高、体重、BMI、血糖、腰椎(L1-L4)、三酰甘油、血糖、总胆固醇、股骨颈骨密度、Ⅰ型胶原氨基端延长肽和β-I型胶原羧基端肽和胃饥饿素水平比较,差异有统计学意义(P均<0.05)。根据Spearman相关分析显示,血清胃饥饿素水平与腰椎和股骨颈BMD呈负相关;和P1NP和β-CTX水平呈正相关,但与三酰甘油、血糖和总胆固醇不相关。结论血清胃饥饿素水平升高可能是绝经后骨质疏松症合并代谢综合征患者骨密度降低的潜在危险因素。

Correlation between ghrelin and bone mineral density in postmenopausal osteoporotic patients with metabolic syndrome

Objective To explore the relationship between ghrelin and bone mineral density(BMD)in patients with postmenopausal osteoporosis complicated with metabolic syndrome.Methods The study included untreated postmenopausal osteoporosis patients(T score<-2.5)who were newly diagnosed in our hospital.A total of 320 female postmenopausal osteoporotic subjects were included.There were 78 patients with metabolic syndrome,and 242 women without metabolic syndrome.Enzyme-linked immunosorbent assay was used to determine the levels of serum ghrelin and bone metabolism indexes.The BMD of the lumbar spine(L1-L4)and femoral neck of each research subject was measured with dual-energy X-ray bone absorptiometry.Pearson correlation analysis was used for correlation analysis between the variables.Results The height,weight,BMI,blood glucose,lumbar spine(L1-L4),triglycerides,blood glucose,total cholesterol,femoral neck BMD,type I collagen amino terminal elongation peptide andβ-I type collagen carboxy terminal peptide,and ghrelin levels between postmenopausal osteoporosis group(OP)and postmenopausal osteoporosis combined with metabolic syndrome group(OPMS)were significantly different(P<0.05).According to Spearman correlation analysis,serum ghrelin levels were negatively correlated with BMD.P1NP was positively correlated withβ-CTX level,but was not correlated with triglycerides,blood glucose,and total cholesterol.Conclusion The increase of serum ghrelin level may be a potential risk factor for postmenopausal osteoporosis complicated with metabolic syndrome.