基于“骨肉不相亲”理论骨与骨骼肌关系的探讨

骨质疏松症和肌肉减少症是老龄化社会常见的增龄性肌骨疾病。现代研究提示,骨与骨骼肌作为共同的功能单位参与了增龄性肌骨疾病的病理过程,从生物力学机制、能量代谢、内分泌、细胞、基因和信号通路等多方面存在相互关联。因此,对骨与骨骼肌关系的研究将有助于预防和治疗此类疾病。中医对骨与骨骼肌关系多从"脾肾"关系来认识,其中,"骨肉不相亲"理论是这种认识的高度概括。现代研究从多维度验证了"骨肉不相亲"理论的合理性。基于"骨肉不相亲"理论和骨与骨骼肌关系的现代研究成果,笔者从生物力学机制、内分泌、能量代谢、基因和信号通路等方面讨论骨与骨骼肌的关系,为骨质疏松症和肌肉减少症等增龄性肌骨疾病的精准防治提供新的思路和有效药物。

Investigation of the relationship between bone and skeletal muscle in view of the disharmony between bone and muscle theory

Osteoporosis and sarcopenia are common musculoskeletal diseases in the aging society. Modern research has shown that bone and skeletal muscle participate in the pathological processes of such diseases as a common functional unit. Bone and skeletal muscle are interrelated in biomechanical mechanisms, energy metabolism, endocrine, cells, genes, and signaling pathways. Therefore research on the relationship between bone and skeletal muscle will contribute to the prevention and treatment of these two diseases. Traditional Chinese Medicine understands the relationship between bone and skeletal muscle from the relationship between "spleen and kidney". Among the theories, "Disharmony between bone and muscle" is a high-level summary of this understanding. Multi-dimensional modern research verifies the rationality of the theory of "Disharmony between bone and muscle ". Based on modern research, this paper discusses the relationship between bone and skeletal muscle in details from biomechanics, endocrine, energy metabolism, gene and molecular level, in order to provide new ideas and effective drugs for the research and precise prevention and treatment of osteoporosis and sarcopenia.