间充质干细胞治疗骨质疏松的研究进展和未来展望

目的 过去20年间（2001年至2020年），间充质干细胞（mesenchymal stem cells，MSCs）已成为许多疾病的潜在治疗方法。然而，目前还没有关于间充质干细胞在骨质疏松症治疗中的研究进展和未来展望的文献计量分析。本文旨在运用文献计量学分析方法，分析过去20年间充质干细胞在骨质疏松症治疗中的研究进展和热点，并预测未来可能的研究趋势。方法 从Web of Science 核心合集（Web of Science Core Collection，WOSCC）中搜索了2001年至2020年所有关于间充质干细胞和骨质疏松症的文献，使用Excel、VOSviewer和CiteSpace软件进行数据分析。分析内容包括：出版物发表趋势、区域分布、作者和机构、关键词分析和热点研究趋势。结果 在过去的20年里，关于MSCs治疗骨质疏松症的文献发表了2 451篇。美国（607篇）和中国（1 154篇）是发表文献和被引用次数最多的国家。大多数发表文献的研究机构都来自中国。排名前五的研究领域集中在组织工程、成骨细胞、衰老、间充质干细胞和核纤层蛋白 A。研究的热点从一开始的体外实验、祖细胞、药物治疗转换到目前的小鼠模型、微小RNA（miRNAs）、支架、骨髓来源的间充质干细胞（BMSCss)、长非编码RNA、细胞外囊泡、外泌体。结论 未来关于MSCs治疗骨质疏松症的研究将继续高速增长，预测未来可能的研究热点是小鼠模型、miRNAs、支架、BMSCs、长非编码RNA、细胞外囊泡和外泌体。

The research progress and perspectives in the treatment of osteoporosis with mesenchymal stem cells

Objective During the last 20 years (2001-2020), mesenchymal stem cells (MSCs) have emerged as a potential treatment for many diseases. However, there is no bibliometric analysis on the progress and future perspectives of MSCs in the treatment of osteoporosis. The purpose of this review is to analyze the research progress and hot spots of MSCs in osteoporosis treatment in the past 20 years using bibliometric analysis and to predict possible future research trend. Methods All literature on MSCs and osteoporosis from 2001 to 2020 was searched from the Web of Science core collection (WOSCC). Data were analyzed using Excel, VOSviewer, and CiteSpace software. The analysis included publication trends, regional distribution, authors and institutions, keyword analysis, and hot research trend. Results Over the past 20 years, 2451 publications on MSCs for osteoporosis were published. The United States (607 articles) and China (1154 articles) were the most published and cited countries. Most of the research institutions that published literature were from China. The top-five research area focused on tissue engineering, osteoblasts, aging, MSCs, and nuclear fibrillar protein A. The hot spots of research included in vitro experiments, progenitor cells, and drug therapy at the beginning, and in mouse models, miRNAs, scaffolds, bone marrow-derived MSCs, long non-coding RNAs, extracellular vesicles, and exosomes at present. Conclusion Future research on MSCs for osteoporosis may continue to grow at a high rate. The possible future research hotspots are predicted to be mouse models, miRNAs, scaffolds, BMSCs, long non-coding RNAs, extracellular vesicles, and exosomes.