基于OPG/RANK/RANKL信号轴探讨中医“瘀证”与骨质疏松症之间的关系

近年来,随着中医学的不断发展,中医药在治疗骨质疏松症(osteoporosis,OP)中的应用愈加广泛,然而由于只有单纯的中医理论指导,而缺乏现代科学依据的支撑,故而广受争议。与此同时,OPG/RANK/RANKL信号轴的发现又是现代分子生物学的一大突破。因此,笔者立足于中西医结合的角度,基于中医脏腑亏虚立论,从OPG/RANK/RANKL信号调控机制探讨中医学从"瘀证"论治骨质疏松症的合理性,从而为中医从"瘀"辨治OP以及临床研究提供科学理论依据。

Study on the relationship between TCM blood stasis syndrome and osteoporosis based on OPG/RANK/RANKL signal axis

In recent years, with the continuous development of traditional Chinese medicine (TCM), the application of TCM in the treatment of osteoporosis (OP) has become more and more widespread. However, due to the simple guidance of TCM theory and the lack of support from modern scientific basis, it is widely disputed. At the same time, the discovery of OPG/RANK/RANKL signal axis is a breakthrough in modern molecular biology. Therefore, in this article, based on the theory of deficiency of viscera and organs of traditional Chinese medicine, the authors explore the rationality of blood stasis in the treatment of OP in traditional Chinese medicine by introducing the mechanism of OPG/RANK/RANKL signal regulation, so as to provide scientific theoretical basis for differentiation and treatment of OP from blood stasis in traditional Chinese medicine and clinical research.