Fas/Fas-L信号系统在绝经后骨质疏松症中作用的研究进展

Fas/Fas-L信号系统是外源性凋亡通路的重要组成部分。近年来大量研究发现,Fas/Fas-L信号系统通过诱导细胞凋亡,不仅参与了免疫系统稳态的维持,而且在骨内环境稳态的调节中也发挥了重要的作用。Fas/Fas-L信号系统在不同骨细胞上的表达和分布可能随体内雌激素水平波动而发生变化。当绝经后雌激素分泌不足时,Fas/Fas-L信号系统可通过启动骨细胞外源性凋亡通路,介导成骨和破骨平衡向破骨方向偏移,参与绝经后骨质疏松症的发生发展。通过调节骨细胞上Fas/Fas-L信号系统来平衡破骨细胞骨吸收和成骨细胞骨形成,将为绝经后骨质疏松症的治疗提供新的思路。

Research progress of Fas/Fas ligand system in postmenopausal osteoporosis

Fas-Fas ligand(FasL) system represents an important mediator of the external apoptotic pathway.Recent studies have shown that Fas/Fas ligand not only play a role in immune system homeostasis but also in the maintenance of bone homeostasis through regulation of apoptosis.The expression and distribution of Fas-Fas ligand system changes substantially with the estrogen level in the body.A decrease in estrogen secretion may trigger the external apoptotic pathway mediated by Fas-Fas ligand system,resulting in the imbalance of osteoclastic bone resorption and osteoblastic bone formation which contributes dramatically to the pathogenesis of osteoporosis.Therapeutic approaches to modify the Fas/Fas ligand system to balance osteoclastic bone resorption and osteoblastic bone formation may pave new ways for the treatment of postmenopausal osteoporosis.