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淫羊藿苷治疗骨性关节炎的研究进展
引用本文:李睿,杨信信,张小辉,马崇文,姜金,夏亚一.淫羊藿苷治疗骨性关节炎的研究进展[J].中国骨质疏松杂志,2018(8):1088-1,092.
作者姓名:李睿  杨信信  张小辉  马崇文  姜金  夏亚一
作者单位:兰州大学第二医院骨科;甘肃省骨关节疾病重点实验室
基金项目:国家自然科学基金面上项目(81672207);甘肃省中医药管理局科研课题(GZK-2017-51)
摘    要:骨性关节炎是一种好发于负重较大的膝关节、髋关节及脊柱等部位的慢性关节疾病,其病因复杂,至今尚未阐明。随着我国人口老龄化的加剧,骨关节炎的发病率不断增高,2015年统计数据发现我国大陆地区骨性关节炎的发病率约为13%。目前临床上针对骨性关节炎有保守及手术等疗法,如膝关节骨性关节炎可保守治疗也可行单髁置换、胫骨高位截骨及双间室置换等手术疗法,手术治疗创伤大,费用高,远期效果并非一劳永逸。而现有的保守疗法远期效果并不显著,所以寻找新的有效的治疗药物显得更为迫切。近年来研究发现淫羊藿苷在治疗骨关节炎方面有着显著的作用,它可促进骨髓间充质干细胞成软骨分化及促进软骨细胞增殖,有效修复骨性关节炎所致的软骨病损;可抑制软骨细胞外基质的降解,延缓骨关节炎所致的软骨组织破坏;可促进成骨细胞增殖,在骨性关节炎早期促进成骨及解除矿化障碍,阻止软骨下骨的进一步病变;可抑制破骨细胞的破骨作用,达到保护软骨下骨的目的;还可抑制炎症因子所致的滑膜炎症反应,缓解关节炎所致疼痛等症状。总之,淫羊藿苷可有效治疗骨性关节炎,尤以早期为著。目前的研究仅局限于组织细胞及动物实验,为明确淫羊藿苷治疗骨性关节炎的有效性及安全性,尚需更多的临床型研究予以证实,这也是今后的研究方向。

关 键 词:骨性关节炎  淫羊藿苷  骨髓间充质干细胞  软骨细胞  软骨下骨

Research progress of Icariin in the treatment of osteoarthritis
LI Rui,YANG Xinxin,ZHANG Xiaohui,MA Chongwen,JIANG Jin,XIA Yayi.Research progress of Icariin in the treatment of osteoarthritis[J].Chinese Journal of Osteoporosis,2018(8):1088-1,092.
Authors:LI Rui  YANG Xinxin  ZHANG Xiaohui  MA Chongwen  JIANG Jin  XIA Yayi
Institution:Orthopedics Department of the Second Hospital of Lanzhou University, Gansu Provincial Key Laboratory of Osteoarthropathy, Lanzhou 730030, China
Abstract:Osteoarthritis is a chronic joint disease that occurs in areas of greater weight-bearing, such as knee, hip and spine. The etiology is complex and has not been fully elucidated yet. With the aggravation of population aging in our country, the incidence of osteoarthritis continues to increase. Statistics show that the incidence of osteoarthritis in mainland China is around 13%. The current clinical treatment of osteoarthritis including conservative and surgical therapy. For example, knee osteoarthritis could have conservative treatment or unicompartmental knee arthroplasty, high tibial osteotomy and double room replacement surgery, etc. Surgical treatment can treat knee osteoarthritis, but involves trauma and high cost, and the effect of the existing conservative treatment is not significant, so finding effective treatment of osteoarthritis becomes even more urgent. In recent years, studies have shown that Icariin has a positive and significant role in the treatment of osteoarthritis. It could effectively promote bone marrow mesenchymal stem cells differentiate into cartilage, promote chondrocyte proliferation, and repair cartilage lesions caused by osteoarthritis. It can inhibit the degradation of cartilage extracellular matrix, and delay the destruction of cartilage tissue caused by osteoarthritis. It can also promote osteoblast proliferation, promote osteogenesis and normalize demineralization disorders at early stage osteoarthritis to prevent further subchondral bone lesions. It can also inhibit osteoclasts activity, and thus protect the subchondral bone. In addition, it can inhibit inflammatory factor-induced synovitis, and relieve pain and other symptoms caused by arthritis. In short, Icariin can treat osteoarthritis effectively, especially in the early stage. Currently studies are limited to tissue and animal experiments, in order to clarify the effectiveness of Icariin in the treatment of osteoarthritis, more clinical studies are needed, which is the direction of future research.
Keywords:Osteoarthritis  Icariin  BMSCs  Chondrocyte  Subchondral bone
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