中医“骨枯髓空”的病理机制及从肾论治原发性骨质疏松症的科学涵义

对原发性骨质疏松症的病因病机进行归纳，阐述了“肾虚-骨枯髓空-骨痿”的病因病机特点及“骨枯髓空”与神经-内分泌-免疫网络的关系，将中医“肾主骨”理论与现代医学神经-内分泌-免疫网络有机结合探讨原发性骨质疏松症（骨痿）“骨枯髓空”的病机特点，以及运用补肾中药防治原发性骨质疏松症的作用机制，为中药防治原发性骨质疏松症提供客观的分子生物学和生物力学依据。

The pathological mechanism of marrow exhausted to bone wither in the Chinese medicine and the scientific meaning of the theory of treatment of primary osteoporosis from the kidney

This review summarizes the pathogenesis of primary osteoporosis, explores the pathogenesis feature of kidney deficiency-marrow exhausted-bone wither-bone atrophy and the relationship with nerve-endocrine-immune network, and discusses pathogenic characteristics of primary osteoporosis (bone atrophy) combined with nerve-endocrine-immune network in modern medicine and the theory of kidney governing bone in Chinese medicine. It also provides an objective molecular biology and biomechanics basis for the prevention and treatment of primary osteoporosis, using the mechanism of kidney notifying medicine.