| 门静脉灌注80%乙醇建立猪肝硬化门静脉高压模型 |
| |
| 引用本文： | 李红彬,王磊,董成宾,邱斌,唐小龙,吴一凡,范振华,刘福全.门静脉灌注80%乙醇建立猪肝硬化门静脉高压模型[J].中国介入影像与治疗学,2017,14(4):247-251. |
| |
| 作者姓名： | 李红彬 王磊 董成宾 邱斌 唐小龙 吴一凡 范振华 刘福全 |
| |
| 作者单位： | 首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038,首都医科大学北京世纪坛医院介入治疗科, 北京 100038 |
| |
| 摘 要： | 目的探讨门静脉灌注80%乙醇建立猪肝硬化门静脉高压动物模型的可行性。方法选取健康贵州小型香猪13只,随机分为3组:实验1组(5只)、2组(5只)及对照组(3只),实验1、2组门静脉分别灌注80%乙醇5ml及10ml,对照组灌注生理盐水10ml,对所有实验猪于灌注前、灌注后即刻、灌注后6周行直接门静脉造影测量门静脉压力及直径;灌注前及灌注后6h内、术后1~6周行肝组织活检;灌注前及灌注后6周分别行增强CT;灌注后6周解剖所有实验猪,对肝脏各叶标本进行组织学检查。结果实验1组及对照组实验猪灌注前、后门静脉直径及压力的差异无统计学意义(P均0.05)。实验2组灌注后即刻、灌注后6周与灌注前比较,门静脉直径及压力的差异均有统计学意义(P均0.05)。实验1、2组灌注后所有实验猪均形成肝纤维化,灌注后6周实验1组2只、实验2组5只纤维化METAVIR评分达4级。结论经门静脉灌注80%乙醇更适宜构建肝硬化门静脉高压动物模型。
|
| 关 键 词： | 乙醇 门静脉灌注 肝硬化 高血压门静脉 动物模型 |
| 收稿时间： | 2016/9/8 0:00:00 |
| 修稿时间： | 2017/1/18 0:00:00 |
Establishes model of liver cirrhosis with portal hypertension by portal infusion of 80% alcohol in swines |
| |
| LI Hongbin,WANG Lei,DONG Chengbin,QIU Bin,TANG Xiaolong,WU Yifan,FAN Zhenhua and LIU Fuquan.Establishes model of liver cirrhosis with portal hypertension by portal infusion of 80% alcohol in swines[J].Chinese Journal of Interventional Imaging and Therapy,2017,14(4):247-251. |
| |
| Authors: | LI Hongbin WANG Lei DONG Chengbin QIU Bin TANG Xiaolong WU Yifan FAN Zhenhua and LIU Fuquan |
| |
| Institution: | Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China,Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China,Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China,Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China,Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China,Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China,Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China and Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China |
| |
| Abstract: | |
| |
| Keywords: | Alcohol Portal infusion Cirrhosis Hypertension portal Animal model |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国介入影像与治疗学》浏览原始摘要信息 |
| 点击此处可从《中国介入影像与治疗学》下载免费的PDF全文 |
|
