番茄红素对血液透析患者静脉铁剂诱导细胞因子的影响

目的：观察维持性血液透析（MHD）患者由静脉铁剂诱导的细胞因子,探讨番茄红素对其的干预作用。方法：60例MHD患者,随机分为两组（对照组和试验组,各30例）。对照组：在患者透析时给予蔗糖铁注射液100mg,2次/周,共10次,观察时间8周。试验组：除蔗糖铁注射液使用外,同时口服番茄红素胶囊,2粒/次,2次/d,用药8周,观察时间8周。观察并比较两组患者治疗前及治疗8周后的白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、白细胞介素-18（IL-18）、肿瘤坏死因子（TNF-α）等细胞因子指标的变化。结果：两组患者治疗后IL-1β、IL-6、IL-8、TNF-α、IL-18水平较治疗前均有显著性升高（P〈0.01或〈0.05）;但是试验组升高幅度显著性小于对照组（P〈0.01）。试验组患者治疗后IL-10水平较治疗前有显著性升高（P〈0.01）;并且试验组升高幅度显著性大于对照组（P〈0.05）。治疗后两组血清IL-1β、IL-6、IL-8、TNF-α、IL-18水平均与铁蛋白（SF）呈正相关（P〈0.01）。结论：静脉铁剂治疗加剧了MHD患者免疫细胞因子的调节;番茄红素可减少细胞因子过度调节而起到抗炎症作用。

Effects of lycopene on Cytokine Induced by Intravenous Iron in Maintenance Hemodialysis Patients

Objective：To observe oxidative stress and inflammation induced by intravenous iron and its prevention by lycopene in maintenance hemodialysis（MHD）patients.Methods：60 MHD patients were randomly divided into two groups：control group（n=30）and treatment group（n=30）.In control group,the patients were treated with iron sucrose,100mg intravenous,during 10 consecutive hemodialysis sessions,twice a week for five weeks.In treatment group,in addition to intravenous iron,the patients were given lycopene,2# oral,twice a day for eight weeks.Their IL-1β,IL-6,IL-8,IL-10,IL-18,TNF-α were measured at pre-and post-treatment.Results：Compared with the pre-treatment,the levels of serum IL-1β,IL-6,IL-8,IL-18 and TNF-α in both groups elevated markedly（P0.01 or 0.05）.but the increament rate of serum L-1β,IL-6,IL-8,IL-18 and TNF-α in treatment group was less than those in control group（P0.01）.Compared with the pre-treatment,the levels of serum IL-10 in treatment groups were elevated significantly（P0.01）.Moreover t the increament rate of IL-10 in treatment group was more than that in control group（P0.05）.At post-treatment,the levels of serum IL-6,IL-8,IL-18 and TNF-α were positively correlated to the levels of SF in both group（P0.01）.Conclusion：Intravenous iron therapy could induce activation of cytokine in MHD patients,which could be alleviated by lycopene.