| Significance of malondialdehyde concentration in seminal plasma of infertile men |
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| 作者姓名： | Xue-JunShang KeLi Zhang-OunYe Yong-GangChen XiaoYu Yu-FengHuang |
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| 作者单位： | [1]1DepartmentofUrology,TongjiHospital,TongjiMedicalCollege,HuazhongScience＆TechnologyUniversity,Wuhan,430030,China [2]LaboratoryofReproduction＆Genetics,NanjingGeneralHospitalofNanjingCommand,PLA,Nanjing,210002,China |
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| 摘 要： | Objective: To determine the concentration of malondialdehyde (MDA), product of lipid peroxidation, in seminal plasma and evalu ate its significance. Methods: Ninety-three cases of infertile pa tients were divided into the obstructive azoospermic (12 cases), the non-obstructive azoospermic (15 cases), the oligozoospermic (21 cases), the asthenozoospermic (19 cases), the oligoastheno zoospermic (16 cases) and the oligoasthenoteratozoospermic (10) groups. Eighteen fertile males served as the controls. MDA con centration was assessed by high-performance liquid chromatogra phy (HPLC). Results: With the exception of the obstructive azoospermic group, the MDA concentration in the seminal plasma was significantly different between the control group and the infer tile groups (P<0.01) as well as between the different infertile groups. Conclusion: Determination of MDA concentration in the seminal plasma is helpful to the diagnosis of male infertility induced by overproduction of reactive oxygen species.
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| 关 键 词： | 精液浓度 丙醛浓度 生殖健康 男科学 |
Significance of malondialdehyde concentration in seminal plasma of infertile men |
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| Xue-JunShang KeLi Zhang-OunYe Yong-GangChen XiaoYu Yu-FengHuang.Significance of malondialdehyde concentration in seminal plasma of infertile men[J].Asian Journal of Andrology,2004,6(2):138-138. |
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| Abstract: | Objective: To determine the concentration of malondialdehyde (MDA), product of lipid peroxidation, in seminal plasma and evalu ate its significance. Methods: Ninety-three cases of infertile pa tients were divided into the obstructive azoospermic (12 cases), the non-obstructive azoospermic (15 cases), the oligozoospermic (21 cases), the asthenozoospermic (19 cases), the oligoastheno zoospermic (16 cases) and the oligoasthenoteratozoospermic (10) groups. Eighteen fertile males served as the controls. MDA con centration was assessed by high-performance liquid chromatogra phy (HPLC). Results: With the exception of the obstructive azoospermic group, the MDA concentration in the seminal plasma was significantly different between the control group and the infer tile groups (P<0.01) as well as between the different infertile groups. Conclusion: Determination of MDA concentration in the seminal plasma is helpful to the diagnosis of male infertility induced by overproduction of reactive oxygen species. |
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| Keywords: | malondialdehyde seminal plasma high-performance liquid chromatography male infertility |
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