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Associations between vitamin D and pulmonary function in chronic spinal cord injury |
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| Authors: | Eric Garshick Palak Walia Rebekah L Goldstein Merilee A Teylan Antonio A Lazzari Carlos G Tun |
| Institution: | 1. Pulmonary, Allergy, Sleep, and Critical Care Medicine Section, Medical Service, VA Boston Healthcare System, Boston, Massachusetts, USA;2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA;3. Research and Development Service, VA Boston Healthcare System, Boston, Massachusetts, USA;4. Divison of Primary Care and Rheumatology Section, VA Boston Healthcare System, Boston, Massachusetts, USA;5. Boston University School of Medicine, Boston, Massachusetts, USA;6. Department of Physical Medicine and Rehabilitation, VA Boston Healthcare System, Boston, Massachusetts, USA |
| Abstract: | Context/Objective: Individuals with chronic spinal cord injury (SCI) have an increased risk of morbidity and mortality attributable to respiratory diseases. Previous studies in non-SCI populations suggest that vitamin D may be a determinant of respiratory health. Therefore, we sought to assess if lower vitamin D levels were associated with decreased pulmonary function in persons with chronic SCI. Design: Cross-sectional study. Setting: Veterans Affairs Medical Center. Participants: 312 participants (260 men and 52 women) with chronic SCI recruited from VA Boston and the community participating in an epidemiologic study to assess factors influencing respiratory health. Methods: Participants provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry. Linear regression methods were used to assess cross-sectional associations between plasma 25-hydroxyviatmin D and spirometric measures of pulmonary function. Outcome Measures: Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC. Results: Adjusted and unadjusted for a number of confounders, there was no significant association between plasma vitamin D levels and FEV1, FVC, or FEV1/FVC. For example, in fully adjusted models, each 10?ng/ml increase in vitamin D was associated with a 4.4?ml (95%CI ?64.4, 73.2, P?=?0.90) ml change in FEV1. Conclusion: There was no significant cross-sectional association between plasma vitamin D and FEV1, FVC, or FEV1/FVC in this cohort of individuals with chronic SCI. |
| Keywords: | Vitamin D Pulmonary function Spinal cord injury |