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庆大霉素重组合异种骨复合体防治开放性骨折骨缺损感染的实验研究
引用本文:粟向东,胡蕴玉.庆大霉素重组合异种骨复合体防治开放性骨折骨缺损感染的实验研究[J].中华骨科杂志,1999,19(12):730-734.
作者姓名:粟向东  胡蕴玉
作者单位:第四军医大学西京医院全军创伤骨科研究所!西安,710032,第四军医大学西京医院全军创伤骨科研究所!西安,710032
基金项目:全军95指令性课题基金!96L052
摘    要:目的 研制庆大霉素重组合异种骨复合体(gentamicin-reconstiuted bone xenograft-composite,G-RBX-C),为临床防治开放性骨折骨缺损感染提供理论依据。方法 采用具有高效骨诱导及骨肟导能力的重组合民种骨作为载体,复合庆大霉素制备庆大霉素后组合异种骨复合体,并对其体内药物释放特性、异位诱导成骨能力及骨缺损修复能力进行了研究。结果 体内药物释放试验显示:G

关 键 词:庆大霉素  开放性骨折  骨移植  骨缺损  G-RBX-C

Experimental Study of Gentamicin-Reconstituted Bone Xenograft- Composite for Prophylaxis and Treatment of Bone Infections and Bone Defects After Open Fracture
LI Xiangdong,HU Yunyu..Experimental Study of Gentamicin-Reconstituted Bone Xenograft- Composite for Prophylaxis and Treatment of Bone Infections and Bone Defects After Open Fracture[J].Chinese Journal of Orthopaedics,1999,19(12):730-734.
Authors:LI Xiangdong  HU Yunyu
Abstract:Objective To prepare gentamicin - reconstituted hone xenograft - composite(G -- RBX -- C) with the purpose of giving further information for its clinical application in prophylaxis and treatment of bone infections and bone defects after open fracture. Methods RBX as a bone grafting material which has the capabilities of osteoinduction and osteoconduction was used in combination with gentamicin to prepare a gentamicin -- RBX -- composite. The release test of gentamicin from these composites in vivo and its capabilities of ectopic bone induction and reparing segmental radial defects of rabbits were evaluated. Results in vivo release test of gentamicin revealed a high concentration level of antibiotics which sustained for at least ten days. In the study of ectopic bone induction, there was abundant woven bone in G -- RBX -- C group 2 weeks after the operation. The study of repairing segmental radial defects of rabbits showed abundant chondral and new bone islands at the site of the defects 4 weeks after operation, a number of new ossicles formed and increased in size by the sib week, and an early medullary canal appeared to be forming which contained marrow elements like substances by the 16th week. Conclussion G -- RBX -- C is of competent sustained release profile in vivo test and has the capabilities of ectopic bone induction and reparing large segmental nonunion defects. It might serve as a new hone grafting material in the prophylaxis and treatment of bone infections and bone defects after open fracture.
Keywords:Gentamicins Fractures  open Bone transplantation
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