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Expression Analysis Elucidates the Roles of MAML1 and Twist1 in Esophageal Squamous Cell Carcinoma Aggressiveness and Metastasis |
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| Authors: | Mohammad Mahdi Forghanifard Omeed Moaven Moein Farshchian Mehdi Montazer Reza Raeisossadati Abbas Abdollahi Meysam Moghbeli Taher Nejadsattari Kazem Parivar Mohammad Reza Abbaszadegan |
| Institution: | (1) Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;(2) Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran;(3) Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;(4) Human Genetic Division, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran;(5) Department of Pathology, Omid Hospital, MUMS, Mashhad, Iran;(6) Department of Surgery, Omid Hospital, MUMS, Mashhad, Iran;(7) Division of Human Genetics, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, 9196773117, Iran |
| Abstract: | BackgroundEpithelial-mesenchymal transition has recently attracted great attention in studying the malignant progression of cells through a converging pathway of oncogenesis and metastasis. Twist1 and Mastermind-like 1 (MAML1) are major regulators of EMT through different pathways. The aim of this study was to investigate the clinicopathological relevance of the expression of MAML-1 and Twist1 genes in esophageal squamous cell carcinoma (ESCC). |
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