胃肠道癌症患者血清性激素含量变化及其意义

目的　探讨血清性激素水平变化在胃肠道癌症的诊断和治疗的作用。方法　检测５８ 例胃肠道癌症患者和５０ 例胃肠道良性疾病患者手术前后血清性激素含量变化，并与５０ 名健康人对照。结果　男女癌症患者的睾酮水平在术前均低于良性疾病组和健康组（ Ｐ ＜ ０－０１），手术后明显提高（ Ｐ＜ ０－０１） 。女性患者的雌二醇水平在术前低于良性疾病组和健康组（ Ｐ＜ ０－０１） ，手术后明显提高（ Ｐ＜ ０－０１） 。男性患者的雌二醇水平在术前高于良性疾病组和健康组（ Ｐ＜ ０－０５），手术后明显降低（ Ｐ＜０－０１）。良性疾病组与健康组比，良性疾病组手术前后比，上述两种激素水平均无明显差异（ Ｐ ＞ ０－０５） 。结论　血清性激素水平测定对胃肠道癌症的诊断和治疗有一定的意义。

Changes and its significance of serum sex hormones in gastrointestinal cancer

Objective Toinvestigate the effect of changes of sex hormones in patients with gastrointestinal cancer on diagnosis and treatment. Methods Serum estrogen level (SEL) and serum testosteronelevel(STL) were detected in 58 healthy subjects as control. Results STLwas significantly lowerin male and female cancer cases before operation than thatin benign and control group ( P < 0-01) ,and increased significantly after operation ( P< 0-01) .SELwas significantly higherin male cancercases before operation thanthatin benign and controlgroup ( P< 0-05) ,and significantly decreased after operation ( P < 0-05) . SEL was significantly lower in female cancer cases before operation than that in benign and control group ( P < 0-05) , and increased significantly after operation ( P < 0-01) . STLand SELhad no difference between benign and control group ,pre and post operation of benign group . Conclusion Itis significantto detect the level of serum sex hormonefor the diagnosis and treatment of gastrointestinalcancer.