丙烯酸类骨水泥混合硫酸钙联合经皮椎体后凸成形术治疗骨质疏松性骨折

目的:探究丙烯酸类骨水泥(polymethyl methacrylate,PMMA)混合硫酸钙联合经皮椎体后凸成形术(percutanouskyphoplasty,PKP)治疗骨质疏松性骨折(osteoprosis vertebral compression fracture,OVCF)的临床疗效。方法:对2020年1月至2021年3月收治的191例采用PKP术式治疗的OVCF患者的临床资料进行回顾性分析,其中82例共94个椎体应用PMMA混合硫酸钙进行治疗,设为观察组;109例共125个椎体应用单纯PMMA进行治疗,设为对照组。观察组男16例,女66例,年龄(75.35±11.22)岁,包括36个胸椎,58个腰椎;对照组男22例,女87例,年龄(74.51±9.21)岁,包括63个胸椎,62个腰椎。通过统计两组患者的手术时间、出血量、骨水泥注入量,术前及术后1 d、3个月、1年的疼痛视觉模拟评分(visual analogue scale,VAS)、Oswestry功能障碍指数(Oswestry disability index,ODI)、Cobb角、椎体高度以及术后骨水泥渗漏的发生...

Effect of acrylic bone cement mixed with calcium sulfate combined with percutaneous kyphoplasty in the treatment of osteoporotic fractures

Objective To investigate the clinical efficacy of acrylic cement (PMMA) mixed with calcium sulfate combined with percutaneous kyphoplasty (PKP) in the treatment of osteoporotic fracture (OVCF).Methods The clinical data of 191 patients with OVCF treated with PKP from January 2020 to March 2021 were retrospectively analyzed. Among them,82 patients with 94 vertebral bodies were treated with PMMA mixed with calcium sulfate as the observation group,and 109 patients with 125 vertebral bodies were treated with pure PMMA as the control group. Among the 82 patients in the observation group,there were 16 males and 66 females,with a mean age of (75.35±11.22) years old,including 36 thoracic vertebrae and 58 lumbar vertebrae. In the control group,there were 109 patients,22 males and 87 females,with an average age of (74.51±9.21) years old,including 63 thoracic vertebrae and 62 lumbar vertebrae. The visual analog scale (VAS) before operation and 1 day,3 months and 1 year after operation were calculated. The Oswestry disability index (ODI),Cobb''s angle,vertebral body height and the probability of postoperative bone cement leakage were used to analyze the efficacy of the two groups.Results All the patients were followed up for more than one year. Compared with the control group,there was no significant difference in operation time,bleeding volume and bone cement injection volume between the two groups(P>0.05),while the leakage rate of bone cement was significantly lower in the observation group (P<0.05). In addition,there was no significant difference in VAS,ODI,Cobb angle,and vertebral body height between the two groups before operation,and 1 day,3 months,and 1 year after operation (P>0.05),but each index was improved compared with that before operation (P<0.05).Conclusion PMMA mixed with calcium sulfate has equivalent efficacy in treating OVCF than PMMA alone,but can effectively reduce the probability of cement leakage.