胶原蛋白水凝胶在软骨组织工程中的应用

由创伤或骨病所致的关节骨软骨损伤在临床中十分常见,其中软骨缺损者达40.31%。由于关节软骨自身修复能力低下,采用组织工程技术对关节软骨损伤进行修复是目前采用再生医学治疗关节软骨损伤的新方法。组织工程支架按照性状可分为预成型支架材料及水凝胶材料两大类。传统的预成型支架材料移植技术容易给缺损周边软骨带来继发损伤,也存在支架与缺损整合不紧密等问题。如何在避免二次损伤的基础上,应用理想的仿生材料复合种子细胞修复关节不规则软骨损伤将成为未来软骨损伤修复的主要问题。选取微创、仿生并且可以原位塑形的胶原蛋白水凝胶复合种子细胞修复关节软骨损伤为损伤关节软骨的修复带来了希望。本文结合国内外相关文献对目前胶原蛋白水凝胶在软骨组织工程中的应用做一综述。

Application of collagen hydrogel in cartilage tissue engineering

Articular osteocartilage injury caused by trauma or bone disease is very common in clinical practices,the proportion of cartilage defects reached 40.31%.As the low self healing abilities of articular cartilage,the technology of tissue engineering becomes a new method to treat articular cartilage injuries with regenerative medicine.Scaffolds can be divided into pre-formed and hydrogel scaffolds according to properties.The traditional graft of pre-formed scaffold will bring the secondary injury to the cartilage around the defect,and the loose graft intergration with the defect surface is still a problem.Repairing irregular articular cartilage defects with ideal biomimic materials on the basis of avoiding secondary damage will become a main issue.The method of minimally invasive injecting,biomimics,and in situ remodeling brings hope to articular cartilage repairing.Below is a summary of the international and domestics reference data of recent years on collagen hydrogel in cartilage tissue engineering.