富血小板血浆复合脱蛋白异种骨在腰椎后外侧融合术中的应用

目的将富血小板血浆复合脱蛋白异种骨应用于腰椎后外侧融合术，评价其近期临床疗效。方法将40例患者随机分入试验组和对照组（各20例），试验组采用脱蛋白牛松质骨＋PRP作为骨移植材料，对照组采用单纯脱蛋白牛松质骨为骨移植材料。观察骨融合、骨移植物降解及椎间隙高度等情况。结果2组均无排异反应。术后1-3个月，2组病例在椎间隙高度、椎体间角、椎体后凸角上均无明显变化。术后6个月，2组在椎间高度变化以及椎间角变化上无明显差异（P〉0．05），而在后凸角变化上，对照组明显〉试验组（P〈0．05）。12个月时2组在椎间高度变化、椎间角变化以及后凸角变化上的差异有统计学意义（P〈0．05）。结论富血小板血浆复合脱蛋白异种骨促进骨融合的能力是一种良好的组合方式。

Application of platelet rich plasma combined with deproteined bovine cancellous bone in the posterolateral fusion of lumbar

Objective The platelet rich plasma combined with deproteined bovine cancellous bone was applied in the posterolateral fusion of lumbar and the initial stage effect was evaluated. Methods Froty patients were treated with lumbar fusion which were randomly assigned into 2 groups: experimental group and control group. There were 20 cases in each group. Platelet rich plasma combined with deproteined bovine cancellous bone was transplanted in the experimental group and deproteined bovine cancellous bone was applied in the control group. The effect of lumbar fusion was evaluated by bone fusion, disappearance of bone transplant and alteration of disc height and so on. Results Rejection reaction was not found on 2 groups. There was no obvious difference between 2 groups from 1 to 3 months after operation. And there was no obvious difference between 2 groups in alteration of disc height and intervertebral angle 6 months after operation(P>0.05). But the alteration of kyphosis angle in the experimental group was more distinct than which in the control group(P<0.05). There was obvious difference between 2 groups in alteration of disc height, intervertebral angle and kyphosis angle 12 months post-operatively(P<0.05). Conclusion The platelet rich plasma combined with deproteined bovine cancellous bone could enhance the bone healing obviously.