瑞芬太尼心肌保护作用的研究进展

背景瑞芬太尼是一超短效阿片受体激动剂，可有效抑制心血管应激反应，维持血液动力学稳定；研究发现瑞芬太尼预处理及后处理可减轻心肌缺血/再灌注损伤（ischemia/reperfusion injury，I/RI）。目的就瑞芬太尼心肌保护作用的研究进展作一综述，使人们系统地了解瑞芬太尼的心肌保护作用及其可能机制。内容主要从瑞...

Progress in myocardial protective effect of remifentanil

Background Remifentanil is an ultra-short-acting agonist to opioid receptor, which inhibits the cardiovascular stress response and maintains the hemodynamic stability. Studies on it had found that preconditioning and postconditioning with remifentanil could reduce myocardial ischemia reperfusion injury. Objective This review focused on the researches in myocardial protective effect of, remifentanil, offeringa systematic understanding of the cardioprotective effect of remifentanil and its possible mechanisms. Content This review included the following parts: Pharmacokinetics and pharmacodynamics of remifentanil;Inhibiting the excessive stress response which resulted in myocardial injury; The cardioprotective effect of remifentanil preconditioning and postconditioning and its possible mechanisms. Trend In recent years, several studies have reported that remifentanil preconditioning and postconditioning confer myocardial protection effect, but the clinical use of it is still relatively limited. Therefore, the myocardial protective effects of remifentanil preconditioning and postconditioning in patients and its possible mechanisms need further study.