| 全身麻醉药诱发睡眠紊乱的研究进展 |
| |
| 引用本文： | 常静,陈畅,张宗泽.全身麻醉药诱发睡眠紊乱的研究进展[J].国际麻醉学与复苏杂志,2021,42(2):176-179. |
| |
| 作者姓名： | 常静 陈畅 张宗泽 |
| |
| 作者单位： | 武汉大学中南医院麻醉科 430071 |
| |
| 基金项目： | 国家自然科学基金(81771160,81671060)。 |
| |
| 摘 要： | 全身麻醉药可干扰机体的昼夜节律,诱发术后睡眠紊乱,但其具体的机制尚未完全阐明。研究表明,全身麻醉药可通过激活γ-氨基丁酸(γ-aminobutyric acid,GABA)能受体、抑制NMDA受体引起昼夜节律紊乱。文章简要阐明全身麻醉药诱发睡眠紊乱的机制,重点阐释时钟基因(circadian locomotor output kaput,Clock)在其中发挥的作用,有助于改善围手术期患者的睡眠问题,以期推进舒适化医疗;通过进一步阐释昼夜节律对全身麻醉药的作用,有助于提高麻醉质量,实现精准麻醉。
|
| 关 键 词： | 麻醉药，全身 睡眠紊乱 昼夜节律 时钟基因 |
Research progress on sleep disturbance induced by general anesthetics |
| |
| Chang Jing,Chen Chang,Zhang Zongze.Research progress on sleep disturbance induced by general anesthetics[J].international journal of anesthesiology and resuscitation,2021,42(2):176-179. |
| |
| Authors: | Chang Jing Chen Chang Zhang Zongze |
| |
| Institution: | (Department of Anesthesiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China) |
| |
| Abstract: | General anesthetics may induce post?operative sleep disturbance through disturbing circadian rhythm.However,the mechanisms involved have not been fully understood.Recent studies show that,general anesthetics activateγ?aminobutyric acid(GABA)?ergic receptors and inhibit N?methyl?D?aspartate(NMDA)receptors to disturb circadian rhythm.The current review introduces the mechanisms underlying sleep disturbance induced by general anesthetics and thoroughly discusses the role of circadian locomotor output kaput(Clock)genes involved,which will improve sleep problems and promote comfortable medical care for perioperative patients.Further investigationintohowcircadianrhythmaffectsgeneralanestheticsishelpfultoimproveanesthesiaqualityandachievepreciseanesthesia. |
| |
| Keywords: | Anesthetics general Sleep disturbance Circadian rhythm Clock gene |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
