Neuropsychological and Quality of Life Changes Following Unilateral Thalamic Deep Brain Stimulation in Parkinson's Disease: A One-Year Follow-up |
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| Authors: | S P Woods J A Fields K E Lyons W C Koller S B Wilkinson R Pahwa A I Tröster |
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| Institution: | (1) Department of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA, US;(2) Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA, US;(3) Division of Neurosurgery, University of Kansas Medical Center, Kansas City, Kansas, USA, US;(4) Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA, US;(5) Departments of Psychiatry & Behavioral Sciences and of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, USA, US |
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| Abstract: | Summary.
Background: The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in
patients with intractable Parkinson's disease (PD) have not heretofore been described.
Method: Six patients diagnosed with PD underwent unilateral DBS implantation into a verified thalamic VIM nucleus target. Participants
completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery.
Findings: Compared to their presurgical scores, PD patients exhibited significant improvement on measures of conceptualization, verbal
memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests.
Interpretation: These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation
in patients with PD. |
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| Keywords: | : Neuropsychology quality of life Parkinson's disease deep brain stimulation |
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