The effect of induced metabolic acidosis on vitamin D3 metabolism in rachitic chicks |
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Authors: | B Sauveur M Garabedian C Fellot P Mongin S Balsan |
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Institution: | (1) Station de Recherches Avicoles, I.N.R.A. Nouzilly, F-37380 Monnaie, France;(2) Laboratoire des Tissus Calcifiés (C.N.R.S.), Hôpital des Enfants Malades, Paris, France |
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Abstract: | Summary The metabolism of vitamin D3 was studied in 3-week-old, vitamin D deficient chicks, fed since hatching with a diet containing 3% ammonium chloride, 1% calcium, and 0.7% phosphorus. When kidney homogenates were incubated in vitro with 3H]25-(OH)D3, the production of 1,25-(OH)2D3 was reduced by 40% in acidotic birds. During in vivo experiments, after injection of 3H]D3 (1220 pM/bird), the level of 1,25-(OH)2D3 was also reduced in blood plasma, intestine, and tibiae in acidotic chicks as compared with the controls. As a large increase in plasma phosphate was found during acidosis, these results are discussed in relation to the possible role of phosphorus in the control of 1,25-(OH)2D3 synthesis. |
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Keywords: | Vitamin D Metabolic acidosis Phosphorus |
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