首页 | 本学科首页   官方微博 | 高级检索  
检索        


Changes in lipids during matrix: Induced endochondral bone formation
Authors:A L Boskey  A H Reddi
Institution:(1) Hospital for Special Surgery and Cornell University Medical College, 10021 New York, NY;(2) Bone Cell Biology Section, Laboratory of Biological Structure, National Institute for Dental Research, National Institutes of Health, 20205 Bethesda, Maryland, USA
Abstract:Summary The changes in lipids occurring during the process of endochondral ossification have been characterized by studying the discrete phases of matrix-induced endochondral bone formation in the rat. Calcium-acidic phospholipid-phosphate complexes were shown to increase in concentration during cartilage calcification (day 9) and to peak in content during early bone formation (day 11–13), the times during which the rate of mineral deposition, as indicated by the change in ash weight was greatest. These data support the hypothesis that the calcium-acidic phospholipid-phosphate complexes play a role in thein vivo initiation of hydroxyapatite deposition. The overall lipid composition of the induced matrix newly formed cartilage (days 7–9) was comparable to that of normal cartilage, with the phospholipid composition matching that of chondrocyte plasma membranes. Times of vascular invasion and formation of marrow cavities were marked by elevated total lipid and triglyceride contents.
Keywords:Endochondral ossification  Acidic phospholipids  Mineralization  Bone induction
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号