Combination therapy of hydrogel and stem cells for diabetic wound healing |
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Authors: | Jia-Na Huang Hao Cao Kai-Ying Liang Li-Ping Cui Yan Li |
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Institution: | Jia-Na Huang, Hao Cao, Kai-Ying Liang, Yan Li, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong Province, ChinaJia-Na Huang, Hao Cao, Kai-Ying Liang, Yan Li, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, ChinaLi-Ping Cui, Endocrinology Department, Panyu Central Hospital, Guangzhou 511400, Guangdong Province, China |
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Abstract: | Diabetic wounds (DWs) are a common complication of diabetes mellitus; DWs have a low cure rate and likely recurrence, thus affecting the quality of patients’ lives. As traditional therapy cannot effectively improve DW closure, DW has become a severe clinical medical problem worldwide. Unlike routine wound healing, DW is difficult to heal because of its chronically arrested inflammatory phase. Although mesenchymal stem cells and their secreted cytokines can alleviate oxidative stress and stimulate angiogenesis in wounds, thereby promoting wound healing, the biological activity of mesenchymal stem cells is compromised by direct injection, which hinders their therapeutic effect. Hydro-gels form a three-dimensional network that mimics the extracellular matrix, which can provide shelter for stem cells in the inflammatory microenvironment with reactive oxygen species in DW, and maintains the survival and viability of stem cells. This review summarizes the mechanisms and applications of stem cells and hydrogels in treating DW; additionally, it focuses on the different applications of therapy combining hydrogel and stem cells for DW treatment. |
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Keywords: | Combination therapy Mesenchymal stem cells Hydrogel Diabetic wound Cells delivery Wound healing |
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| 点击此处可从《World journal of diabetes》浏览原始摘要信息 |
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