| 丹酚酸B和高氧液对兔肢体缺血再灌注损伤代谢酶的影响 |
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| 引用本文： | 涂泽松,陈志维,李逸群.丹酚酸B和高氧液对兔肢体缺血再灌注损伤代谢酶的影响[J].河南外科学杂志,2010,16(4). |
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| 作者姓名： | 涂泽松 陈志维 李逸群 |
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| 作者单位： | 广东佛山市中医院骨科,佛山,528000 |
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| 摘 要： | 目的探讨高氧液和丹酚酸B对肢体缺血再灌注损伤的影响。方法选用健康新西兰家兔24只,随机分为4组,在缺血前从耳缘静脉推注等量的生理盐水(A组)、高氧液(B组)、丹酚酸B(C组)或高氧液加丹酚酸B(D组),夹阻股动静脉,建立肢体缺血再灌注损伤模型,在缺血前和再灌注4h抽血检测LDH、CK,取腓肠肌作LDH酶组织化学染色。结果再灌注4h,血清肌酸激酶活性较前明显升高,高氧液和丹酚酸B可以抑制其升高(P0.01),两者有协同作用(P=0.05);血清乳酸脱氢酶活性较前明显升高,高氧液和丹酚酸B可以抑制其升高(P0.01),两者有协同作用(P0.01)。LDH酶组织化学显色见:相对于对照组其他组组织织LDH酶活性较低,以联合用药组最低。结论高氧液和丹酚酸B对缺血再灌注损伤起预防作用,而且两者有协同作用。
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| 关 键 词： | 高氧液 丹酚酸B 缺血再灌注损伤 |
Investigate the effects of Salvianoli acid B and hyperoxic solution on experimental Ischemia reperfusion in-jury of extremity |
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| Tu Zesong,Cheng Zhiwei,L Li Zhiwei.Investigate the effects of Salvianoli acid B and hyperoxic solution on experimental Ischemia reperfusion in-jury of extremity[J].Henan JOurnal of Surgery,2010,16(4). |
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| Authors: | Tu Zesong Cheng Zhiwei L Li Zhiwei |
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| Institution: | Tu Zesong,Cheng Zhiwei,L Li Zhiwei.Department of Orthopadics,Guangdong Fushan traditional hospital,Fushan 528000 China |
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| Abstract: | Objective Aim to investigate the effects of Salvianoli acid B and hyperoxic solution on experimental Ischemia reperfusion injury of extremity.Methods twenty-four healthy New Zealand rabbits were divided into four groups randomly.Equivalent 0.9%Nacl(A group),hyperoxic solution(B),Salvianoli acid B(C),Salvianoli acid B and hyperoxic solution(D) were injected through ear edge vein before ischemia.The femoral artery and vein was blocked and set up the model of ischemia reperfusion injury of extremity.Before isc... |
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| Keywords: | Hyperoxic solution Salvianoli acid B Ischemia Reperfusion Injury |
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