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DDX家族与肿瘤的相关性研究进展
引用本文:张业骞,曹晖.DDX家族与肿瘤的相关性研究进展[J].国际外科学杂志,2017,44(5).
作者姓名:张业骞  曹晖
作者单位:上海交通大学医学院附属仁济医院胃肠外科,上海,200127
摘    要:DEAD-box家族是一类以D(Asp)-E(Glu)-A(Ala)-D(Asp)为保守序列的RNA解旋酶家族,参与需要RNA调节的所有细胞过程.研究表明,DDX家族很多成员在肿瘤组织中表达失调,并且参与肿瘤的发生、发展,在肿瘤细胞的增殖、凋亡、细胞周期、侵袭、转移以及代谢等方面发挥关键作用,可以作为肿瘤的诊断、恶性程度的评价、临床预后的预测等新的分子标志物,也为肿瘤的治疗提供了新的潜在分子靶标.本文就DDX家族的结构、功能、以及与肿瘤的关系作一综述.

关 键 词:DEAD盒蛋白  DEAD-box  RNA解旋酶类  肿瘤  综述

Effects of DDX family on cancer development and progression
Zhang Yeqian,Cao Hui.Effects of DDX family on cancer development and progression[J].International Journal of Surgery,2017,44(5).
Authors:Zhang Yeqian  Cao Hui
Abstract:DEAD box family,characterized by the conserved motif D (Asp)-E (Glu)-A (Ala)-D (Asp),are putative RNA helicases,which participate in all cellular processes regulated by RNAs.Studies show that there are examples of dysregulation of DDX family expression in various types of cancer.They are involved in the occurrence and evolution of tumor,and take part in tumor cell proliferation,apoptosis,cycle,invasion,metastasis and metabolism,which can be acted as new molecular markers for the diagnosis of tumor,the evaluation of malignancy and the prediction of clinical prognosis and also provide new potential molecular targets for tumor therapy.Here,we reviewed the structure,biochemical function and the relationship with tumor of DDX family.
Keywords:DEAD-box protein  DEAD-box RNA helicases  Neoplasms  Review
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