Talin及Integrin/FAK信号通路与肝癌

肿瘤细胞黏附能力的改变是肿瘤细胞侵袭和转移的起始;整合素(integrin)是细胞表面重要的黏附分子受体,介导许多信号通路的发生,包括Integrin/黏着斑激酶(focal adhesion kinase,FAK)信号通路,直接或间接地影响肿瘤复发和转移,其中Integrin/FAK信号转导通路,在Integrin介导的肝癌黏附转移信号转导通路中起着至关重要的作用.踝蛋白(Talin)是第一个被证实的Integrin活化蛋白,是黏着斑(focal adhesion plaque,FAP)结构的重要组成部分.本文就Talin结构、功能、与Integrin/FAK信号通路的相互作用及其与肝癌及其他肿瘤的关系作一综述.

Relationship between Talin and its signaling pathway and hepatocellular carcinoma

Alterations of cell adhesion of tumor cells is the initial step of invasion and metastasis of tumor cells.Integrin receptors are cell surface receptors with critical functions in cell adhesion and migration,which can mediate many signaling pathway occurred,including the integrin/FAK signaling pathway,directly or indirectly affecting tumor recurrence and metastasis.Integrin/FAK signaling pathway is thought to play an impartant role in integrin-mediated signaling transduction pathway leading to adhesion and metastasis of hepatocellular carcinoma.Talin is the first cytoskeletal protein that has been proposed to act as the final common step in integrin activation,which is a major component of the focal adhesion.This study reviews the construction and function of talin,its reaction with integrin/FAK signaling pathway,as well as its relationship with hepatocellular carcinoma and other tumors.