| PEG-PLGA纳米颗粒载体药物靶向治疗肿瘤的研究进展 |
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| 引用本文： | 陈刚,李玉民,刘涛,何雯婷.PEG-PLGA纳米颗粒载体药物靶向治疗肿瘤的研究进展[J].国际外科学杂志,2010,37(6). |
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| 作者姓名： | 陈刚 李玉民 刘涛 何雯婷 |
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| 作者单位： | 1. 730000,兰州,甘肃省消化肿瘤重点实验室,兰州大学第二医院;兰州大学第一临床医学院普外科
2. 甘肃省消化肿瘤重点实验室,兰州大学第二医院,兰州,730000 |
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| 基金项目： | 863计划重点项目课题 |
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| 摘 要： | 肿瘤是近年来临床多发的难治性疾病,是导致死亡的主要原因之一,手术及放、化疗是常规治疗手段.但晚期转移者无法手术,传统放、化疗缺乏针对性,且多有严重不良反应,致使人们普遍关注靶向治疗,因此,其已成为一个热点问题.本文纳入大量相关中外文献,综述并讨论近年来以PEG-PLGA纳米粒子为载体治疗肿瘤的靶向给药系统的研究进展,并分析了存在的问题.
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| 关 键 词： | 聚乙丙交酯聚乙二醇 纳米颗粒 靶向给药系统 肿瘤靶向治疗 |
Development of PEG-PLGA nanoparticles as drug carrier with tumor-targeted therapy |
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| CHEN Gang,LI Yu-min,LIU Tao,HE Wen-ting.Development of PEG-PLGA nanoparticles as drug carrier with tumor-targeted therapy[J].International Journal of Surgery,2010,37(6). |
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| Authors: | CHEN Gang LI Yu-min LIU Tao HE Wen-ting |
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| Abstract: | In recent years, tumor is a refractory disease occurring frequently which is the main cause of death. Surgery, radiotherapy and chemotherapy are the usual therapeutic tools. However,radiotherapy and chemotherapy have serious side-effects and surgery can not be used effectively when metastasis happened. Therefore, tumor-targeted therapy has developed as a better way to cure tumor. Development of research on the use of PEG-PLGA nanoparticles as drug carriers are reviewed in this article, furthermore, problems about that are analysed. |
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| Keywords: | Polylactide-co-glycolide-co-poly ( ethyleneglycol) Nanoparticles Targeting drug delivery system Tumor-targeted therapy |
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