血红素加氧酶-1在异种移植适应现象中的研究进展

血红素加氧酶（heine oxygenase，HO）是血红素降解过程中的限速酶，HO-1在体内外实验已被证实具有抗炎症、抗凋亡、调节细胞分化作用，对器官移植的缺血再灌注损伤具有保护作用。适应（accommodation）是指受体体内存在抗供体的抗体，但移植物仍然可以被接受的现象，其发生机制目前还不清楚。新近报道在适应的异种移植动物模型中出现HO-1的高表达。HO-1高表达是否与异种移植免疫保护存在关联，是否参与适应机制的产生，目前还没有定论。HO-1是否通过其反应的下游产物产生保护作用，其机制尚不明了。目前，如何将异种移植物引入适应状态是异种移植研究的热点之一。理解HO-1与异种移植，尤其是与适应有关的异种移植之间的关系具有重要的临床应用前景。

The effect of heme oxygenase-1 on accommodation in xenotransplantation

Heme oxygenase catalyzes the rate-limiting step in heme degradation.Besides its physiological role in heme degradation,HO-1 may influence a number of cellular processes,including growth,inflammation,apoptosis,and alleviated ischemia/reperfusion(I/R) injury.Accommodation is the mechanism that might allow a graft to survive in the face of an immune response directed against it,which involved complex elusive interactions.A higher expression of HO-1 has been observed in accommodation animal model.Until now there was no final conclusion whether overexpression HO-1 has definite relation of the protection in xenotransplantation,whether HO-1 takes part in the development of accommodation.Whether HO-1 supplies the protection through its derived products,or that its enzymatic reaction products possess the protection as well is still unknown.Nowadays,how to lead the xenograft into accommodation is a hot spot.Further understanding the relationship between HO-1 and xenotransplantation,especially accommodation,has a potential clinical application.