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甲状腺术后的甲状腺功能维护
引用本文:苏艳军,杨婷婷,张建明,程若川.甲状腺术后的甲状腺功能维护[J].国际外科学杂志,2014,41(2):114-119.
作者姓名:苏艳军  杨婷婷  张建明  程若川
作者单位:苏艳军 (650032昆明,昆明医科大学第一附属医院甲状腺疾病诊治中心,云南省甲状腺外科临床研究中心); 杨婷婷 (650032昆明,昆明医科大学第一附属医院甲状腺疾病诊治中心,云南省甲状腺外科临床研究中心); 张建明 (650032昆明,昆明医科大学第一附属医院甲状腺疾病诊治中心,云南省甲状腺外科临床研究中心); 程若川 (650032昆明,昆明医科大学第一附属医院甲状腺疾病诊治中心,云南省甲状腺外科临床研究中心);
摘    要:甲状腺功能减退是甲状腺手术最常见的并发症.左甲状腺素钠(L-T4)是治疗甲状腺功能减退的首选药物,甲状腺功能维护可于术后早期进行,L-T4的需要量受多个因素及目标TSH的影响,实施过程中应考虑患者的特殊性(依从性差、妊娠、老年),并定期(4~6周)复查甲状腺功能,根据目标TSH调整最佳用药剂量,避免治疗不足和治疗过度.T3分次给药或L-T4/T3联合治疗可作为L-T4治疗失败患者的选择.

关 键 词:甲状腺切除术  甲状腺功能减退症  激素替代治疗  TSH抑制治疗  手术后并发症

Thyroid function maintenance following thyroidectomy
Su Yanjun,Yang Tingting,Zhang Jianming,Cheng Ruochuan.Thyroid function maintenance following thyroidectomy[J].International Journal of Surgery,2014,41(2):114-119.
Authors:Su Yanjun  Yang Tingting  Zhang Jianming  Cheng Ruochuan
Institution:( Department of Diagnosis and Treatment Center of Thyroid Disease, First Affiliated Hospital of Kunming Medical University, Clinical Research Center of Thyroid Surgery in Yunnan Province, Kunming 650032, China)
Abstract:Postoperative hypothyroidism is the most common complication following thyroidectomy,and thyroxine replacement is needed to maintain thyroid function.Levothyroxine (L-T4) is the preferred drug for the treatment of hypothyroidism.L-T4 therapy can be initiated immediately after thyroid operation,and the dosages are influenced by target serum TSH and several other factors.Special consideration should be taken for such patients,including patients with poor compliance,during pregnancy,and elderly patients.Thyroid function should be measured every 4 to 6 weeks,optimal dosages are adjusted according to target serum TSH individually,avoiding under-treatment or over-treatment.T3 in divided doses or L-T4/T3 combination therapy can be served as alternative for those failed to L-T4 therapy alone.
Keywords:Thyroidectomy  Hypothyroidism  Hormone replacement therapy  TSH-Suppressive therapy  Postoperative complications
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