| 糖尿病大鼠血糖波动对肝脏功能及超微结构的影响 |
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| 引用本文： | 李素娟,刘浩,李剑敏,陆鸣,龚一女,金可可,王万铁.糖尿病大鼠血糖波动对肝脏功能及超微结构的影响[J].肝胆胰外科杂志,2011,23(1):7-10. |
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| 作者姓名： | 李素娟 刘浩 李剑敏 陆鸣 龚一女 金可可 王万铁 |
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| 作者单位： | 温州医学院病理生理教研室;河南科技大学人体解剖教研室;温州医学院第一附属医院病理科;温州医学院第二临床医学院; |
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| 基金项目： | 浙江省自然科学基金资助项目(Y207495) |
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| 摘 要： | 目的 建立糖尿病(diabetes mellitus,DM)大鼠血糖渡动模型,观察血糖波动对DM大鼠肝脏损伤的作用.方法 SD 大鼠24只均分为3组,A组为正常对照组,B组为稳定高血糖组,C组为波动血糖组,B组、C组大鼠均一次性腹腔内注射链脲佐菌素(STZ)65 mg/kg,建立DM模型.C组每天错时给予胰岛素和50%...
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| 关 键 词： | 血糖 糖尿病 大鼠 肝脏 |
Effects of fluctuant high blood glucose on hepatic function and ultrastructure in diabetic rats |
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| LI Su-juan,LIU Hao,LI Jian-min,et al..Effects of fluctuant high blood glucose on hepatic function and ultrastructure in diabetic rats[J].Journal of Hepatopancreatobiliary Surgery,2011,23(1):7-10. |
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| Authors: | LI Su-juan LIU Hao LI Jian-min |
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| Institution: | LI Su-juan*,LIU Hao,LI Jian-min,et al.* Department of Pathophysiology,Wenzhou Medical College,Wenzhou Zhejiang,325035 |
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| Abstract: | Objective To establish the animal model of diabetic rats with fluctuant high blood glucose and observe the effects of fluctuant high blood glucose on liver in diabetic rats.Methods Twenty-four SD rats were divided into 3 groups,including control group(group A),stable high blood glucose group(group B) and fluctuant high blood glucose group(group C).Diabetes mellitus model was induced by an intraperitoneal injection of STZ at a dose of 65 mg/kg body weight in group B and group C.Fluctuant high blood glucose m... |
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| Keywords: | blood glucose diabetes mellitus rats liver |
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