胰胆管合流异常肝损伤抗氧化治疗的实验研究

目的 研究胰胆管合流异常(APBDU)肝损伤的抗氧化治疗.方法 采用13只健康杂种猫,建立胰胆管合流异常的动物模型后随机分为:A组7只,不进行抗氧化治疗;B组6只,抗氧化治疗;术前的13只作为对照组.饲养6个月观察肝脏的病理和肝脏过氧化产物丙二醛(maleic dialdehyde,MDA)变化.结果 13只猫均成活6...

The experiment study of the anti-oxidative treatment in Liver with anomalous pancreaticobiliary ductal union

Objective To evaluate the anti-oxidative treatment in cats with anomalous pancreaticobiliary ductal union.Methods Thirteen healthy cats as control group which were made a model resembling the common channel of anomalous pancreaticobiliary ductal union in humans were divided randomly into two groups: 7 cats in group A were not treated,6 cats in group B were treated with melatonin,vitamin C and vitamin E.Six months later,the livers of these cats were removed and histopathological changes were evaluated by pathological and electron microscopic examination.The levels of MDA in livers were test.Results Thirteen cats in control group showed that the color of liver was salmon pink and no nodus in liver.In A group,the color of liver became deeper and a little nodus was found in liver.Histopathology showed ballooning changes in liver cells,mitochondria swelling and lipid droplet in intracytoplasm.One cats in group B had the same change as the group A.The other 5 cats had fewer changes than that in group A both in pathological and electron microscopic examination.The levels of MDA in livers were different between the group A,B and the control group after 6 months(4.697±1.957 nmol/mgprot,1.273±0.889 nmol/mgprot,0.789±0.860 nmol/mgprot,P=0.001,F=17.43).Conclusion The anti-oxidative treatment is effective to the anomalous pancreaticobiliary ductal union.