β-纤维蛋白原-455G/A基因多态性与胆囊癌的相关性研

目的 通过检测胆囊癌患者β-纤维蛋白原（Fgβ）-455G/A基因，探讨Fgβ-455G/A基因多态性与胆囊癌的相关性。方法 采集50 例胆囊癌患者（胆囊癌组）和50 例胆囊结石伴慢性胆囊炎患者（胆囊炎组）的静脉血，应用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF-MS）方法对Fgβ-455进行基因分型。 结果 Fgβ-455 基因GA杂合型和AA纯合子在胆囊癌中的频率显著高于胆囊炎组，显著增加胆囊癌发生的危险性，OR值（95%CI）分别为2.526（1.052～6.068）和4.306（1.177～15.749）。结论 Fgβ-455G/A位点G/A单个碱基的改变可能在胆囊癌的发病中起着重要的作用。

Correlation between gene polymorphisms of β-fibrinogen-455G/A and gallbladder cancer

Objective To investigate the association between gene polymorphism of β-fibrinogen (Fgβ)-455G/A and gallbladder cancer (GBC) by detecting the Fgβ-455G/A gene in patients with GBC. Methods Venous blood was collected from 50 patients with GBC (gallbladder cancer group) and 50 patients with gallstone and chronic cholecystitis (cholecystitis group). The genotypes of Fgβ-455G/A were determined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Results The frequencies of Fgβ-455G/A with type GA and type AA in GBC group were significantly higher than those in the cholecystitis group, which significantly increased the incidence risk of GBC (OR 2.526 and 4.306, respectively; 95%CI 1.052~6.068 and 1.177~15.749, respectively). Conclusion The change of single base of G/A in Fgβ-455G/A may play an important role in the pathogenesis of GBC.