| 无精子及严重少精子症的遗传学缺陷分析 |
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| 引用本文： | 蔡军,蔡稔.无精子及严重少精子症的遗传学缺陷分析[J].中国男科学杂志,2004,18(5):48-50. |
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| 作者姓名： | 蔡军 蔡稔 |
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| 作者单位： | 1. 广西柳州市妇幼保健院生殖中心,柳州,545001
2. 广西柳州市妇幼保健院遗传优生科 |
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| 摘 要： | 目的 探讨遗传缺陷在无精子、严重少精子症中的检测意义。方法 采用细胞遗传学技术及多重聚合酶链反应(PCR)技术对65例无精子及严重少精子症患者进行染色体核型分析、Y染色体无精子因子(AZF)检测，同时行精索输精管诊察，阴性者行精液果糖定量实验。结果 染色体核型异常8例(12．3％)，AZF因子缺失7例(10．8％)，输精管缺如2例(3.1％)。结论 遗传学检测在男性无精子、严重少精子症有重要意义。
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| 关 键 词： | 无精子 严重少精症 染色体 无精子因子 输精管缺如 |
| 修稿时间： | 2004年7月14日 |
Hereditary deficiency analysis in azoospermia and severe oligozoospermia |
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| Cai Jun Procreation Center the Maternity and Child Health Institute,Liuzhou ,ChinaCai RenHeredity Prepotency Section the Maternity and Child Health Institute.Hereditary deficiency analysis in azoospermia and severe oligozoospermia[J].Chinese Journal of Andrology,2004,18(5):48-50. |
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| Authors: | Cai Jun Procreation Center the Maternity and Child Health Institute Liuzhou ChinaCai RenHeredity Prepotency Section the Maternity and Child Health Institute |
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| Institution: | Cai Jun Procreation Center the Maternity and Child Health Institute,Liuzhou 545001,ChinaCai RenHeredity Prepotency Section the Maternity and Child Health Institute |
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| Abstract: | Objective To investigate the significance about hereditary deficiency of azoospermia and severeoligozoospermia. Methods By the technology of cytogenetics and PCR in chromosome style and AZF analysis, 65cases of idiopathic azoospermia and severe oligozoospermia were tested. At the same time, vas deferens were palpated, andfructose was tested when it is negative. Results 8 cases abnormal chromosome karyotgpes(12.3%), 7 cases AZF factordeletion (10.8%), and 2 cases absence of vas deferens(3.1%) were found. Conclusions There is great significance forhereditary disease test in male azoospermia and severe oligozoospermia. |
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| Keywords: | azoospermia severe oligozoospermia chromosome AZF absence of vas deferens |
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