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Thymosin beta 10 correlates with lymph node metastases of papillary thyroid carcinoma
Authors:Xiao-Jun Zhang  Yao-Rong Su  Dan Liu  De-Bin Xu  Mu-Sheng Zeng  Wen-Kuan Chen
Affiliation:1. Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China;2. State Key Laboratory of Oncology in South China, Guangzhou, P. R. China;3. Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China;4. Department of General Surgery, Jiangmen Central Hospital, Jiangmen, P. R. China;5. Department of General Surgery, The Fifth People''s Hospital of Shenzhen, Shenzhen, P. R. China;6. Department of Thyroid Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China;g Laboratory of Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
Abstract:

Background

Thymosin beta 10 (TMSB10) has recently been recognized as being an important player in the metastatic cascade including tumor angiogenesis, invasion, and metastasis. However, a role for this protein in papillary thyroid carcinoma (PTC) has not yet been established.

Methods

Real-time polymerase chain reaction was used to examine the expression of TMSB10 messenger RNA in 36 cases of thyroid tissue samples: normal thyroid, PTC without lymph node metastases (LNM) and PTC with LNM (n = 12 cases in each subgroup). For immunohistochemistry, 130 patients with PTC were selected during the period of 2004–2005, 91 with and 39 without LNM. Statistical analysis was applied to evaluate the correlation between TMSB10 expression and LNM of PTC.

Results

By real-time polymerase chain reaction analysis, the expression of TMSB10 messenger RNA in normal thyroid tissue, PTC without LNM, and PTC with LNM tissue were significantly different (P < 0.0001). On immunohistochemistry analysis of 130 patients with PTC, in which 91 cases had cervical LNM and 69 cases had central neck LNM, high expression levels for TMSB10 were more common in patients with cervical LNM compared with patients without (81% versus 33%, P < 0.001). Similarly, high expression levels of TMSB10 were more common in patients with central neck LNM compared with those without (87.0% versus 44.3%, P < 0.001).

Conclusions

High expression levels of TMSB10 correlated with LNM in PTC, especially in the central neck region. Patients with PTC with low levels of TMSB10 expression may be unlikely to have central neck LNM and could therefore avoid prophylactic central neck dissection.
Keywords:Papillary thyroid carcinoma   Lymph node metastasis   Thymosin beta 10   Central neck dissection
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